地塞米松磷酸钠注射液联合支持疗法治疗葡萄球菌性烫伤样皮肤综合征临床观察

Clinical effects of dexamethasone sodium phosphate injection combined with supporting therapy in treatment of staphylococcal scalded skin syndrome

目的葡萄球菌性烫伤样皮肤综合征是临床常见重症皮肤感染病,临床具有起病较急及病情发展较为迅速等特点,近年来该病患病率不断增加,患者若不及时治疗,严重时可导致其死亡,严重危害居民身体健康及生命安全,临床积极寻求一种高效治疗方式尤为重要。本研究探讨地塞米松磷酸钠注射液联合支持疗法治疗葡萄球菌性烫伤样皮肤综合征的临床效果。方法选择2016-03-10-2018-01-12本院收治的84例葡萄球菌性烫伤样皮肤综合征患儿作为研究对象,采用组间年龄、性别和病程匹配的方法,选择观察组与对照组,各42例。对照组采用足量抗生素治疗,观察组在此基础上采用肾上腺皮质激素联合支持疗法治疗。比较两组临床疗效和临床症状缓解时间。结果治疗后,观察组总有效率为97.62%(41/42),高于对照组的80.95%(34/42),差异有统计学意义,χ^2=4.480,P<0.05。观察组红斑萎缩时间为(3.10±0.84)d,短于对照组的(3.96±1.23)d,t=3.742,P<0.05;触痛消失时间为(3.24±0.87)d,短于对照组的(4.06±1.01)d,t=3.987,P<0.05;完全结痂时间为(6.24±1.97)d,短于对照组的(8.36±2.14)d,t=4.724,P<0.05;皮肤松懈停止时间为(4.25±1.53)d,短于对照组的(6.04±1.87)d,t=4.801,P<0.05;住院时间为(9.36±4.12)d,短于对照组的(13.87±5.41)d,t=4.298,P<0.05;尼氏征转阴时间为(3.79±0.36)d,短于对照组的(4.65±0.24)d,t=12.882,P<0.05。结论地塞米松磷酸钠注射液联合支持疗法治疗葡萄球菌性烫伤样皮肤综合征效果确切,可显著缩短患儿临床体征及症状改善时间,利于患者快速康复,缩短病程。

OBJECTIVE Staphylococcal scalded skin syndrome is a common severe skin infection in clinical practice.It has the characteristics of acute onset and rapid development of the disease.In recent years,the prevalence of the disease has been increasing.If the patient is not treated in time,it will become serious and cause death,seriously endangering people’s health and safety.Therefore,it is especially important to actively seek an effective treatment method in clinical practice.This study aims to investigate the clinical effects of dexamethasone sodium phosphate injection combined with supporting therapy in treatment of staphylococcal scalded skin syndrome.METHODS A total of 84 children with staphylococcal scalded skin syndrome in our hospital from March 10,2016 to January 12,2018 were divided into observation group and control group according to the age,gender and course of disease,with 42 cases in each group.Control group was treated with adequate antibiotics,and observation group was given adrenocortical hormone combined with supporting therapy based on control group.The clinical efficacy and recovery time of clinical symptoms were compared between the two groups.RESULTS After treatment,the total effective rate of observation group was 97.62%(41/42),which was higher than the control group 80.95%(34/42),χ^2=4.480,P<0.05.The erythema shrinking time in observation group was(3.10±0.84)d,which was shorter than that of the control group(3.96±1.23)d,t=3.742,P<0.05;The tenderness disappearance time in observation group was(3.24±0.87)d,which was shorter than that of the control group(4.06±1.01)d,t=3.987,P<0.05;The total incrustation time in observation group was(6.24±1.97)d,which was shorter than that of the control group(8.36±2.14)d,t=4.724,P<0.05;The stop time of skin relaxing in observation group was(4.25±1.53)d,which was shorter than that of the control group(6.04±1.87)d,t=4.801,P<0.05;The hospital stays in observation group was(9.36±4.12)d,which was shorter than that of the control group(13.87±5.41)d,t=4.298,P<0.05;The negative conversion time of Nikolsky’s sign in observation group was(3.79±0.36)d,which was shorter than that in control group(4.65±0.24)d,t=12.882,P<0.05.CONCLUSION Adrenocortical hormone combined with supporting therapy in treatment of staphylococcal scalded skin syndrome is effective,it can shorten improvement time of clinical signs and symptoms,promote quick recovery and shorten course of disease.