外周血嗜酸性粒细胞与并发Hp感染心肌梗死相关性分析

Relationship between peripheral blood eosinophils and myocardial infarction complicated by Hp infection

目的急性心肌梗死(acute myocardial infarction,AMI)是常见的心血管疾病,患者预后较差。外周血嗜酸性粒细胞(eosinophils,EOS)、幽门螺杆菌(helicobactor pylori,Hp)感染与心肌梗死患者发病密切相关。本研究探讨EOS和并发Hp感染心肌梗死患者的关系。方法选取2016-03-02-2018-03-02河南省胸科医院收治的224例冠心病患者为研究对象,按照冠心病发病类型,心肌梗死并发Hp感染患者为病例组,心肌梗死未并发Hp感染患者为对照组。所有患者均接受14C尿素呼气试验。统计患者临床资料,对可能造成AMI患者发生Hp感染的相关因素进行Logistic多因素回归分析。结果单因素分析结果显示,病例组EOS计数为(0.11±0.07)×10^9 L^-1,低于对照组的(0.20±0.09)×10^9 L^-1,差异有统计学意义,t=2.687,P=0.005;病例组男性、长期吸烟史、白细胞计数和血清超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平高于对照组,差异均有统计学意义,均P<0.05;病例组收缩压、舒张压、高血压病史和高脂血症病史低于对照组,差异均有统计学意义,均P<0.05。多因素Logistic回归分析结果显示,在排除了其他因素的干扰作用后,EOS计数仍然与AMI患者发生Hp感染有关联,EOS计数降低,并发Hp感染心肌梗死危险性增加,OR=0.423,95%CI为0.209~0.856,P=0.024。结论EOS计数与并发Hp感染心肌梗死有关联,可以作为AMI患者并发Hp感染的相关检测指标。

OBJECTIVE Acute myocardial infarction(AMI)is a common cardiovascular disease with poor prognosis.Peripheral blood eosinophils(EOS)and Helicobacter pylori(Hp)infection are closely related to the incidence of myocardial infarction.This study investigated the relationship between EOS and myocardial infarction complicated with Hp infection.METHODS A total of 224 patients with coronary heart disease admitted to Henan Thoracic Hospital from March 2,2016 to March 2,2018 were selected as the study subjects.According to the type of coronary heart disease,patients with myocardial infarction complicated with Hp infection were selected as the case group,while those without Hp infection were selected as the control group.All patients received 14C urea breath test.The clinical data of patients were collected and the related factors of Hp infection in patients with AMI were analyzed by logistic regression analysis.RESULTS Univariate analysis showed that the EOS count in the case group was(0.11±0.07)×10^9 L^-1,which was lower than that in the control group(0.20±0.09)×10^9 L^-1,and the difference was statistically significant,t=2.687,P=0.005.In the case group,the male,long-term smoking history,white blood cell count and hs CRP level were higher than those in the control group,the difference was statistically significant(all P<0.05).In the case group,systolic blood pressure,diastolic blood pressure,history of hypertension and history of hyperlipidemia were lower than those in the control group,the difference was statistically significant(all P<0.05).Multivariate logistic regression analysis showed that after excluding the interference of other factors,EOS counts were still associated with the occurrence of Hp infection in patients with AMI.EOS counts decreased,and the risk of myocardial infarction complicated with Hp infection increased,OR=0.423,95%CI was0.209-0.856,P=0.024.CONCLUSIONS EOS count was associated with myocardial infarction complicated with Hp infection.Eos can be used as an indicator of Hp infection in patients with AMI.