4-异丁氧基苄胺的合成

Synthesis of 4-Isobutoxybenzylamine

对羟基苯甲醛和异丁基溴为起始原料经过取代、正向肟化、加氢等合成4-异丁氧基苄胺。对羟基苯甲醛与异丁基溴按摩尔比为1∶2,反应温度为90℃,时间为9h合成4-异丁氧基苯甲醛;4-异丁氧基苯甲醛与盐酸羟胺的摩尔比为1∶2,反应温度为102℃,反应时间为40 h,合成4-异丁氧基苯甲醛肟;4-异丁氧基苯甲醛肟加氢反应在100℃,反应15h合成4-异丁氧基苄胺,4-异丁氧基苄胺总收率达到64%。

4-Isobutoxybenzylamine was synthesized from p-hydroxybenzaldehyde and isobutyl bromide via substitution,forward oxime and hydrogenation.Firstly 4-isobutoxybenzaldehyde was prepared when the molar ratio of p-hydroxybenzaldehyde to isobutyl bromide was 1∶2,the reaction temperature was 90℃a nd the reaction time was 9 h.And then 4-isobutoxybenzaldehyde oxime was prepared when the molar ratio of 4-isobutoxybenzaldehyde to hydroxylamine hydrochloride was 1∶2,the reaction temperature was 102℃,the reaction time was 40 h.At last,4-isobutoxybenzylamine was obtained through the hydrogenation reaction of 4-isobutoxybenzaldehyde oxime for 15 h at 100℃,and the reaction yield reached 64%.