鲁西地区育龄期妇女TORCH感染调查分析

Investigation and analysis of TORCH infection among women of childbearing age in Luxi area

目的探讨鲁西地区育龄期妇女孕前弓形虫(TOX)、巨细胞病毒(CMV)、风疹病毒(RV)的感染状况,为预防TORCH感染和做好优生优育工作提供依据。方法选取2015年12月-2018年6月间来东昌府区妇幼保健院进行免费孕前筛查的妇女共8275例,采用化学发光法检测CMV、TOX、RV的IgG、IgM浓度。结果CMV-IgM阳性率为0.33%,TOX-IgM阳性率为0.22%;CMV感染以春秋两季为高发期,与夏冬两季比较差异有统计学意义(P<0.05);TOX感染春、秋两季与夏、冬两季比较差异无统计学意义(P>0.05);CMV感染四个年龄段(≤25岁、26~35岁、36~45岁、>45岁)的阳性检出率分别为0.11%、0.28%、0.48%、1.83%,TOX感染四个年龄段的阳性检出率分别为0.32%、0.15%、0.37%、0.00%;CMV-IgG的阳性率(95.53%)最高,其次为RV-IgG,阳性率为80.48%,TOX-IgG阳性率最低,仅为0.40%。结论鲁西地区育龄期妇女TORCH感染率较高,尤其以CMV感染率最高,且CMV感染有一定的季节性,以春、秋两季高发。育龄期妇女孕前应及早进行TORCH筛查,旨在有效预防胎儿出生缺陷和患病,改善优生优育。

Objective To explore the infection status of Toxoplasma gondii(TOX),cytomegalovirus(CMV),and rubella virus(RV)in women of childbearing age in Luxi area,and to provide basis for preventing TORCH infection and improving eugenic and reproductive work.Methods A total of 8275 women who came to Dongchangfu Maternal and Child Health Hospital for free pre-pregnancy screening from December 2015 to June 2018 were selected.The concentrations of IgG and IgM of CMV,TOX and RV were detected by chemiluminescence method.Results The positive rates of CMV-IgM and TOX-IgM were 0.33%and 0.22%,respectively.The incidence of CMV infection was higher in spring and autumn than in summer and winter,the difference was statistically significant(P<0.05).There was no significant difference in TOX infection between spring and autumn and summer and winter(P>0.05).The positive detection rates of CMV infection in four age groups(≤25 years old,26-35 years old,36-45 years old and>45 years old)were 0.11%,0.28%,0.48%,1.83%,respectively.The positive detection rates of TOX infection in four age groups were 0.32%,0.15%,0.37%,0.00%,respectively.The positive rate of CMV-IgG(95.53%)was the highest,followed by RV-IgG,the positive rate was 80.48%and the lowest was TOX-IgG,only 0.40%.Conclusion The infection rate of TORCH was higher among women of childbearing age in Luxi area,especially the CMV infection rate was the highest,and CMV infection had a certain seasonality,with a high incidence in spring and autumn.TORCH screening should be carried out as early as possible before pregnancy in order to effectively prevent fetal birth defects and diseases and improve eugenic and eugenic childbearing.