半乳糖凝集素-1在喉鳞状细胞癌中的表达及其与人乳头瘤病毒表达的关系

Expression of galectin-1 in Chinese laryngeal squamous cell carcinoma patients and its clinical significance

目的 观察半乳糖凝集素-l(galectin-1)在喉鳞状细胞癌中的表达及其临床意义。方法 采用免疫组织化学方法检测50例喉鳞状细胞癌组织galectin-1蛋白的表达,同时应用免疫印迹的方法检测其中3例病例的喉癌组织及癌旁组织,并应用统计学方法分析其与临床资料及病理学参数之间的关系。结果 免疫组织化学结果表明,galectin-1蛋白表达的阳性率为74%(37/50),免疫印迹的结果表明3例临床IV期的喉癌组织glactin-1蛋白的表达明显高于癌旁组织。统计学分析glactin-1蛋白的表达与患者临床分期的严重程度、病理分化的严重程度以及具有淋巴结转移之间均具有相关性。结论 glactin-1蛋白的表达与临床分期严重程度、病理分化的严重程度以及具有淋巴结转移呈正相关。

Objective To observe the expression and clinical significance of galectin-1 in Chinese laryngeal squamous cell carcinoma patients.Methods Immunohistochemical technique was used to test the galecin-1 protein expression in the 50 laryngeal squamous cell carcinoma patients and Western blot method was used to test the galecin-1 protein expression in the 3 of the patients.SAS 9.4 software was used to analyze the relationship between the galectin-1 protein and the clinical degrees,pathological grades and lymph node metastasis in all the cases.Results In the 50 laryngeal squamous cell carcinoma patients,the positive rate of galectin-1 protein was 74%(37/50).The expression of galectin-1 protein was correlated with the severity of clinical staging,pathological differentiation and lymph node metastasis.Conclusions High expression of galectin protein related with the occurrence and development of head and neck squamous cell carcinomas.