多肽类药物防治缺血性脑卒中的研究进展

Progress of polypeptide drugs in the prevention and treatment of ischemic stroke

溶栓疗法是临床最常用的治疗缺血性脑卒中的方法,但狭窄的治疗时间窗使其临床应用严重受限,此外,再灌注会进一步引起脑组织损伤,其病理过程和发病机制复杂,氧化损伤、炎症、凋亡、自噬等多种复杂机制参与其中。近年来,越来越多研究表明多肽类药物对缺血性脑卒中(ischemic stroke,IS)的防治具有较好的防治作用。本文按作用机制分别对Hsp27模拟肽、脂联素多肽、NBD多肽、扇贝多肽、HN多肽、R18多肽等多肽类药物防治IS的研究进行综述,为多肽类药物防治IS的深入研究提供参考依据,也为其临床开发与应用提供新的研究思路。

Thrombolytic therapy is the most commonly used for the treatment of ischemic stroke(IS)in the clinic.However,due to the narrow treatment time window,its clinical application is severely limited.In addition,reperfusion can further cause brain tissue damage,and its pathological process and pathogenesis are complex,including oxidative damage,inflammation,apoptosis and autophagy.In recent years,studies show that polypeptide drugs have a better effect on the prevention and treatment of IS.This paper reviews the research on the prevention and treatment of IS by peptide drugs such as HSP27 mimic peptide,adiponectin peptide,NBD peptide,scallop peptide,HN peptide,R18 peptide,etc.,which may provide a reference for the in-depth research on the prevention and treatment of IS by peptide drugs,and also provide a new idea for its clinical development and application.