女性不孕症患者体外受精-胚胎移植助孕周期用药依从性现状及影响因素研究

Study on the status quo and influencing factors of medication adherence in female infertility patients during in vitro fertilization and embryo transfer cycles

目的分析不孕症患者体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)助孕周期用药依从性现状及其影响因素,为今后提高其用药依从性相关干预措施提供依据和思路。方法选取2018年11月至2019年2月期间在兰州大学第一医院生殖中心接受IVF-ET助孕的120例患者为研究对象。采用横断面调查研究,应用一般资料调查表、Morisky用药依从性量(MMAS-8)、一般自我效能感量表(GSES)、社会支持量表(SSRS)和医学应对方式问卷(MCMQ)对120例IVF-ET患者进行调查,采用SPSS25.0软件进行分析。结果IVF-ET患者周期用药依从性得分为(6.70±1.42)分,69.6%的患者用药依从性不高。多因素回归分析结果显示,影响IVF-ET患者用药依从性的主要因素有患者的自我效能及对疾病的医学应对方式。结论IVF-ET患者用药依从性较低,护理人员需要在加强对患者相关用药知识的宣教等措施的基础上,加强IVF-ET周期患者的自我效能,引导其选择“面对”的积极应对方式。在其心理压力大,难以选择“面对”时引导患者采取“回避”应对方式来缓解压力,并制定有效的干预措施,提高其用药依从性。

Objective To analyze the current status of medication adherence and its influencing factors in infertility patients during in vitro fertilization and embryo transfer(IVF-ET)cycles,and to provide evidence and ideas for improving medication adherence and formulating relevant intervention measures in the future.Methods A cross-sectional survey was conducted to investigate 120 patients who underwent IVF-ET using the patient's basic situation questionnaire,MMAS-8,general self-efficacy scale(GSES),social support rating scale(SSRS)and medical coping models questionnaire(MCMQ).And the SPSS25.0 software was used to analyze the results.Results The compliance score of IVF-ET patients was 6.70±1.42,and 69.6%patients had low medication adherence.Multivariate regression analysis showed that the main factors affecting patient compliance were patient self-efficacy and medical response to the disease.Conclusion The current status of IVF-ET assisted patient’s medication adherence need to be further improved.Nursing staff need to not only build on traditional measures such as education,but also strengthen the self-efficacy,guide their choice to face.And when the psychological pressure is too great to be faced,the patient should be guided to adopt an“avoidance”coping style to alleviate the pressure brought by the disease.We should develop effective interventions to improve medication adherence.