脂肪干细胞在伤口愈合中的作用研究进展

Research progress of adipose derived stem cells in wound healing

皮肤是包裹在身体表面的一层组织,是动物抵御外界机械、化学及病原微生物侵袭的第一屏障。皮肤创伤是最常见的外科疾病之一,其愈合过程可概括为:炎症期、增生期和修复期3个阶段。伤口的不完全修复可导致皮肤出现瘢痕,使组织失去正常结构和功能,并严重影响外观美感。传统的治疗方法不能恢复皮肤的正常功能且不良反应明显,已不能满足人们的需求。干细胞治疗,特别是脂肪来源的干细胞(ADSCs)可促进伤口愈合,是近年来研究的热点之一。ADSCs在伤口愈合中可分泌多种生长因子以减轻伤口炎症反应,促进伤口再生上皮化及血管重建,从而促进伤口愈合。在总结伤口愈合过程及其调控机制的同时,对国内外有关ADSCs在伤口愈合中的作用及临床应用进展作一综述。

Skin is a kind of tissue that surrounds the surface of body,it is the first barrier for animals to resist mechanical,chemical and pathogenic microorganisms.Skin wound is one of the most common surgical diseases.The process of wound healing can be summarized as three stages:inflammation stage,fibrous tissue proliferation stage,and scar formation and repair stage.Incomplete repair of the wound leads to skin scarring,which causes the tissue to lose its normal structure and function,and seriously affects the aesthetic appearance.Traditional treatment methods can not restore the normal function of the skin and have obvious adverse reactions,which can not meet people’s needs.Stem cell therapy,especially adipose derived stem cells(ADSCs)plays a essential rule in the process of wound healing making it a research hotspot in recent years.ADSCs can secrete a variety of growth factors during wound healing to reduce wound inflammatory response,promote wound regeneration epithelialization and vascular reconstruction,thereby promoting wound healing.In this paper,the wound healing process and its regulation mechanism were summarized,and the role of ADSCs in wound healing at home and abroad and its clinical application progress were reviewed.