自微乳技术在中药制剂中的应用及其固化研究进展

The application and solidification research progress of self-microemulsion technology in Chinese materia medica preparation

作为一种新型载药体系,自微乳给药系统可明显提高中药难溶性成分的溶解度进而改善其生物利用度。为了解近年来自微乳技术在中药制剂中的应用及其固化研究进展,本文通过查阅相关文献,从自微乳给药系统的组成及优势、自微乳在难溶性中药有效成分中的应用及自微乳的固化研究3个方面进行综述。结果发现,自微乳在黄酮类、萜类、生物碱类、醌类、有机酸类及挥发油类等中药活性成分中均有应用,将自微乳固化之后,其兼具自微乳乳化性能好和固体制剂稳定性佳的优点,可为自微乳给药系统在中药领域的推广应用提供参考。

Self-microemulsifying drug delivery system (SMEDDS) is a new type of drug-loading system,which could significantly increase the solubility of poorly soluble components of traditional Chinese medicine to improve its bioavailability.In order to understand the application of self-microemulsion technology in traditional Chinese medicine preparation and its solidification research progress in recent years,the composition and advantages of SMEDDS,the application of SMEDDS in the effective components of insoluble traditional Chinese medicine and the solidification research of SMEDDS were reviewed by summarizing the related literature.The results showed that SMEDDS was applied in the study of active ingredients of traditional Chinese medicine such as flavonoids,anthraquinones,alkaloids,anthraquinones,organic acids and volatile oil.The solid SMEDDS can combine the advantages of superior self-emulsifying property and good stability,which could provide reference to promote and expand the application of SMEDDS in the field of traditional Chinese medicine.