假基因在心血管疾病中的进展

Role of Pseudogenes in Cardiovascular Diseases

心血管疾病是影响人类寿命的主要疾病,近年来随着科学技术的发展,对这一疾病的分子水平认识更为深入,有研究表明假基因参与心血管疾病的发生发展。假基因是与亲本基因高度同源的非编码基因,因无蛋白质编码功能,曾被称为"垃圾基因",与亲本基因的高度同源性使两者难以鉴别。随着测序技术的不断发展,假基因的鉴定技术逐渐成熟,研究表明假基因与心血管疾病发生、发展密切相关。现通过综述假基因的定义、鉴定、功能及在心血管疾病的作用,加深心血管疾病研究者在这一领域的认识。

Cardiovascular disease is a major disease that affects human life span. In recent years,with the development of scientific research,the molecular level of this disease has been further understood,and some studies have shown that pseudogenes are involved.Pseudogenes are non-coding genes that are highly homologous with the parent genes. It has been called a "junk gene"because it has no protein-coding function,and its high homology with its parents makes it difficult to identify. With the continuous development of sequencing technology,the identification technology of pseudogenes has gradually become mature. Studies have shown that pseudogenes are closely related to the occurrence and development of cardiovascular diseases. This article reviews the definition,identification and function of pseudogenes and their role in cardiovascular disease to deepen the understanding of cardiovascular disease researchers in this field.