心肌梗死后心肌细胞内源性再生的研究进展

Endogenous Regeneration of Myocardial Cells after Myocardial Infarction

成年哺乳动物心脏在心肌梗死后很难再生修复,瘢痕组织的替代会导致心功能的恶化。探索心肌再生的机制并进行可能的临床应用是极其必要的。随着对新生小鼠心肌梗死后心肌再生机制的研究,越来越多的证据表明再生极有可能是由心肌细胞内源性增殖引起的,并探索出细胞周期因子等可能的机制。现对内源性心肌再生的最新研究进展进行综述,初步引入"分子开关模型",并讨论可能的治疗靶点和未来的研究方向。

The adult mammalian heart is difficult to regenerate after myocardial infarction,which inevitably leads to deterioration of cardiac function. Therefore,it is necessary to explore the mechanism of myocardial regeneration in the neonates and make available clinical application. With the deep research on the mechanisms of myocardial regeneration in neonatal mice,more and more evidences show that myocardial regeneration is probably caused by endogenous proliferation,and a number of mechanisms are involved in the process,including cell cycle regulators and others. In this paper,we review the latest research on endogenous myocardial regeneration,introduce the"molecular switch model"preliminarily and discuss the available therapeutic targets and future research directions.