神曲消食口服液治疗功能性消化不良的疗效分析

Analysis of the effectiveness of Shenqu Xiaoshi oral liquid in functional dyspepsia

目的探讨神曲消食口服液对功能性消化不良(functional dyspepsia,FD)疗效。方法选取2015年1月至2018年1月西电集团医院收治的FD患儿200例,依据随机数字表法分为神曲组和对症组,对症组给予FD对症治疗,神曲组在此基础上给予神曲消食口服液治疗,比较2组患者胃肠激素[胃动素(MOT)、胃泌素(GAS)]、FD症状积分、治疗疗效、不良反应。结果神曲组和对症组治疗后MOT、GAS水平明显高于治疗前,神曲组治疗后MOT、GAS水平明显高于对症组,差异均有统计学意义(均P<0.05);神曲组和对症组治疗后FD症状积分明显低于治疗前,神曲组治疗后FD症状积分明显低于对症组,差异均有统计学意义(均P<0.05);神曲组治疗有效率明显高于对症组,差异有统计学意义(P<0.05);神曲组和对症组不良反应发生率比较,差异无统计学意义(P>0.05)。结论神曲消食口服液可有效改善FD患儿胃肠激素、临床症状,有利于提高患儿治疗疗效,具有良好的安全性,值得进一步推广。

Objective To explore the effect of Shenqu Xiaoshi oral liquid on functional dyspepsia(FD).Methods Totally 200 children with FD were selected from January 2015 to January 2018 in Xidian Group Hospital.According to the random digital table method,they were divided into the Shenqu group and the control group.The control group was given FD symptomatic treatment,Shenqu group was given Shenqu Xiaoshi oral liquid treatment on the basis of control group.The gastrointestinal hormones[motilin(MOT),gastrin(GAS)],clinical symptom scores,therapeutic effect and adverse reactions were compared between the two groups.Results After treatment,the MOT and GAS levels in the Shenqu group and the control group were significantly higher than those before the treatment,and the MOT and GAS levels in the Shenqu group were significantly higher than those in the control group,the difference was statistically significant(all P<0.05).After treatment,the FD symptom scores of the Shenqu group and the control group were significantly lower than those before the treatment,and the FD symptom scores in the Shenqu group were significantly lower than those in the control group,the difference was statistically significant(all P<0.05).The treatment effective rate in the Shenqu group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference of the adverse reaction rates between the Shenqu group and the control group(P>0.05).Conclusion Shenqu Xiaoshi oral liquid can effectively improve the gastrointestinal hormones and clinical symptoms in children with FD,which is beneficial to improve the curative effect of children and is safety.It’s worth for further clinical promotion.