摘要
Dear Editor,Amyotrophic lateral sclerosis(ALS)is a progressive and fatal neurodegenerative disease that prominently affects both upper and lower motor neurons.The prevalence of ALS has been estimated at 2.6-3.0 per 100,000 in Europe,5.2 per 100,000 in the USA,and 1.9-9.9 per 100,000 in Asia[1-3].ALS is classified as sporadic(sALS)or familial(fALS),but only 5%-10% of cases are identified as familial[4,5].
基金
supported by the Key Program of the Natural Science Foundation of Guangdong Province,China(2017B030311015)
Guangzhou Municipal People’s Livelihood Science and Technology Project(201803010085)
the National Key R&D Program of China(2017YFC1310200).
