复方玄驹胶囊结合甲磺酸左氧氟沙星片治疗慢性附睾炎临床研究

Clinical observation of Fufang-Xuanju capsule combined levofloxacin mesylate tablets in the treatment of chronic epididymitis

目的评价复方玄驹胶囊结合甲磺酸左氧氟沙星片治疗慢性附睾炎的疗效。方法选择2016年12月-2019年2月中国中医科学院西苑医院泌尿外科76例慢性附睾炎患者,按治疗方法分为治疗组43例和对照组33例。对照组口服甲磺酸左氧氟沙星片,治疗组在对照组基础上加用复方玄驹胶囊。2组均治疗4周。采用慢性附睾炎症状指数量表(Chronic Epididymitis Symptom Index,CESI)进行疼痛评分及生活质量评分,评价临床疗效。结果治疗组总有效为83.7%(36/43)、对照组为63.6%(26/33),2组比较差异有统计学意义(χ^2=4.020,P=0.045)。与同组治疗前比较,2组治疗后2、4周疼痛评分、生活质量评分、总分均降低(P<0.01)。治疗组疼痛评分、生活质量评分、总分治疗后2周(F值分别为16.132,9.134、23.681)、治疗后4周(F值分别28.7410、74.049、72.483)均低于对照组(P<0.01)。结论复方玄驹胶囊结合甲磺酸左氧氟沙星片可减轻慢性附睾炎患者的疼痛程度,改善生活质量,提高临床疗效。

Objective To evaluate the efficacy of Fufang-Xuanju capsule combined with levofloxacin mesylate tablets in the treatment of chronic epididymitis.Methods A total of 76 patients in the Urology Department of Xiyuan Hospital of China Academy of Chinese Medical Sciences who met the inclusion criteria from December 2016 to February 2019,were divided into treatment group(43 cases)and control group(33 cases).The control group was given levofloxacin mesylate tablets orally.The treatment group was given Fufang-Xuanju capsule based on the control group.Both groups were treated for 4 weeks.Chronic epididymitis symptom index(CESI)was used to evaluate the clinical efficacy by pain score and quality of life score.Results The total effective rate was 83.7%(36/43)in the treatment group and 63.6%(26/33)in the control group.There was statistically significant difference between the two groups(χ^2=4.020,P=0.045).Compared with baseline,the pain scores,quality of life scores and total scores of both groups at 2,4 weeks after treatment were significantly lower(P<0.01).Two weeks after the treatment,the pain scores,quality of life scores and total scores in the treatment group were significantly lower than those of the control group(F value were 16.132,9.134 and 23.681,respectively,all Ps<0.01).And 4 weeks after the treatment,the pain scores,quality of life scores and total scores of the treatment group were significantly lower than that of the control group(F value were 28.741,74.049,72.483,respectively,all Ps<0.01).Conclusions Fufang-Xuanju capsule combined with levofloxacin mesylate tablets can alleviate the pain of patients with chronic epididymitis,improve the quality of life and improve the clinical efficacy.