牙龈卟啉单胞菌与阿尔茨海默病的相关性研究进展

Recent advance in relation between porphyromonas gingivalis and Alzheimer's disease

牙龈卟啉单胞菌是慢性牙周炎(CP)的主要致病菌。近年来发现其与阿尔茨海默病(AD)的发生与发展相关,牙龈卟啉单胞菌的感染可能增加AD的发病风险,但机制尚不明确。体外研究和动物实验证明,抑制牙龈卟啉单胞菌主要毒力因子牙龈蛋白酶可以减轻神经变性、降低β淀粉样蛋白沉积,控制AD进程。本文现围绕近年来牙龈卟啉单胞菌与AD的相关性研究进展综述如下,以期为探寻AD的预防和治疗新策略提供参考。

Porphyromonas gingivalis(P.gingivalis)is the main pathogen of chronic periodontitis(CP).It has been found in recent years that P.gingivalis is associated with the occurrence and development of Alzheimer's disease(AD).P.gingivalis infection may increase the risk of AD,but the pathogenesis remains unclear.In vitro and animal experiments showed that inhibition of gingipains,the main virulence factor of P.gingivalis,could reduce neurodegeneration,decrease the deposition of beta-amyloid protein and control the progression of AD.This article reviews the research progress between P.gingivalis and AD in recent years,and provides references for exploring new prevention and treatment strategies of AD.