CYP1A1基因rs4646903位点基因多态性与男性特发性不育的相关性研究:meta分析

Association between CYP1A1 gene rs4646903 polymorphism and male idiopathic infertility:meta-analysis

目的探讨CYP1A1基因rs4646903位点多态性与特发性男性不育的关系。方法采用Cochrane系统评价方法,检索电子数据库PUBMED、MEDLINE、EMBASE及CNKI,所有数据库检索时间限定为自建库以来至2018年8月31日,并手工检索相关参考文献,对所纳入的病例对照研究采用Stata 12.0统计软件进行分析。结果检索到文献56篇,最终纳入8项病例对照研究,包括病例组1640例不育男性和对照组1794例正常生育男性。综合分析,在等位基因模型(OR=1.39,95%CI:1.05;1.84)、纯合子模型(OR=2.17,95%CI:1.24;3.79)、显性模型(OR=1.44,95%CI:1.02;2.03)和隐形模型(OR=1.83,95%CI:1.15;2.89)中观察到CYP1A1基因rs4646903位点多态性与特发性男性不育显著相关,而与野生纯合型TT比较,杂合性CT(OR=1.32,95%CI:0.97;1.79)与特发性男性不育无相关性。然而,所有的比较模型中,在进一步的亚组分析中未明确与特发性男性不育的易感性关系。结论CYP1A1基因rs4646903位点基因多态性可能是特发性男性不育发生的影响因素之一。

【Objective】To investigate the relationship between CYP1A1 gene rs4646903 polymorphism and idiopathic male infertility.【Methods】Using the Cochrane systematic review method,we searched the electronic databases PUBMED,MEDLINE,EMBASE,and CNKI.All database retrieval time was limited to self-built database to August 31,2018,and related references were manually searched for the included case-control study.We used the Stata 12.0 statistical software for analysis.【Results】A total of 56 articles were retrieved and 8 case-control studies were included,including 1640 infertile men in the case group and 1794 normal males in the control group.Through comprehensive analysis,in the allelic model(OR=1.39,95%CI:1.05;1.84),homozygous model(OR=2.17,95%CI:1.24;3.79),dominant model(OR=1.44,95%CI:1.02;2.03)and the invisible model(OR=1.83,95%CI:1.15;2.89),we observed that CYP1A1 gene rs4646903 polymorphism was significantly associated with idiopathic male infertility,compared with wild homozygous TT,heterozygous CT(OR=1.32,95%CI:0.97;1.79)was not associated with idiopathic male infertility.However,in all comparative models,the susceptibility to idiopathic male infertility was not clearly identified in further subgroup analyses.【Conclusion】The rs4646903 polymorphism of CYP1A1 gene may be one of the influencing factors of idiopathic male infertility.