KIF23在结直肠癌中的表达及其临床意义

Expression of KIF23 in colorectal cancer and its clinical significance

目的:探讨KIF23在结直肠癌中的表达及其临床意义。方法:分析TCGA数据库中KIF23 mRNA在结直肠癌中的表达。分析2010年2月至2013年2月于河南大学淮河医院行手术治疗的116例结直肠癌组织标本及患者临床病理资料,通过免疫组织化学法检测KIF23在结直肠癌组织中的表达,分析其与临床病理参数及预后的相关性。结果:TCGA数据库分析结果表明,癌组织中KIF23 mRNA表达水平增高(P<0.05)。免疫组织化学法检测结果提示61.2%(71/116)的结直肠癌组织中KIF23蛋白表达阳性。KIF23蛋白表达与T、N、M及TNM分期有相关性(P<0.05)。Kaplan-Meier生存分析提示与低表达KIF23相比,高表达KIF23患者的总生存时间、无复发生存时间显著缩短(P<0.05)。Cox回归分析提示KIF23是影响结直肠癌患者预后的独立危险因素。结论:KIF23在结直肠癌中高表达,可能成为预测结直肠癌患者发生发展及预后的分子标记物。

Objective:To investigate the expression and clinical significance of KIF23 in colorectal cancer(CRC).Methods:The Cancer Genome Atlas(TCGA)database was used to analyze KIF23 mRNA expression in CRC tissues.A total of 116 patients with CRC tissue specimens and clinicopathological data were collected from Huaihe hospital of Henan University for this study from February 2010 to February 2013,and KIF23 protein was detected by immunohistochemistry.Moreover,the association between KIF23 expression and clinicopathological characteristics was analyzed.Results:TCGA database analysis showed that the KIF23 mRNA expression level is increased in cancer tissue(P<0.05).KIF23 was detected in 61.2%of CRC tissues by immunohistochemistry.Overexpression of KIF23 in CRC tissues was associated with T,N,M,and TNMstages(P<0.05).Kaplan-Meier survival analysis showed that increased KIF23 expression was strongly associated with shorter overall survival and disease-free survival compared with patients with low KIF23 expression(P<0.001).Cox proportional hazard regression confirmed that KIF23 was an independent prognostic factor in patients with CRC.Conclusions:KIF23 is highly expressed in CRC and is a potential molecular marker to predict the occurrence,development,and prognosis of CRC.