阿司匹林与替格瑞洛联合治疗急性心肌梗死的临床观察

Clinical observation of aspirin combined with ticagrelor in the treatment of acute myocardial infarction

目的分析阿司匹林与替格瑞洛联合治疗急性心肌梗死的临床效果。方法选取我院2018年2月~2019年2月收治的100例急性心肌梗死患者为研究对象,以就诊奇偶顺序将其分为观察组与对照组,每组50例。对照组予阿司匹林联合氢氯吡格雷治疗,观察组予阿司匹林、替格瑞洛联合治疗。比较两组患者的心功能指标、凝血功能指标变化及不良反应发生率。结果两组治疗后的LVEF、LVEDD水平均有不同改善,观察组的LVEF(61.28±4.23)%高于对照组(50.78±5.02)%,LVEDD(40.13±4.14)mm低于对照组(46.98±4.30)mm(t=4.702、3.166,P=0.009、0.018);观察组的PT(21.78±4.01)s、TT(18.64±2.01)s、ATPP(83.45±7.98)s、D-D(2.39±0.27)μg/mL水平均高于对照组(17.46±5.11)s、(16.42±2.02)s、(73.66±7.13)s、(2.04±0.20)μg/mL(t=2.028、2.118、2.368、2.523,P=0.048、0.037、0.028、0.016);观察组不良反应发生率(8.00%)低于对照组(24.00%)(χ^2 =4.762,P=0.029)。结论阿司匹林与替格瑞洛联合治疗急性心肌梗死的疗效显著,其不仅能够有效改善患者的心功能与凝血功能,还能减少用药的不良反应。

Objective To analyze the clinical effect of aspirin combined with ticagrelor in the treatment of acute myocardial infarction(AMI).Methods A total of 100 patients with AMI admitted in our hospital from February 2018 to February 2019 were selected as the study subjects.They were divided into observation group and control group,with 50 cases in each group.The control group was treated with aspirin and clopidogrel,while the observation group was treated with aspirin and ticagrelor.The changes of cardiac function index,coagulation function index and the incidence of adverse reactions were compared between the two groups.Results After treatment,left ventricular ejection fraction(LVEF)and left ventricular end-diastolic dimension(LVEDD)in both groups were improved,and the LVEF in the observation group(61.28±4.23)%was higher than that in the control group(50.78±5.02)%,LVEDD in the observation group(40.13±4.14)mm was lower than that in the control group(46.98±4.30)mm,and the difference was statistically significant(t=4.702,3.166,P=0.009,0.018);Protothrombin time(PT),thrombin time(TT),active part thrombin time(ATPP)and D-Dimer(D-D)of the observation group[(21.78±4.01)s,(18.64±2.01)s,(83.45±7.98)s and(2.39±0.27)μg/mL]were higher than those of the control group[(17.46±5.11)s,(16.42±2.02)s,(73.66±7.13)s,(2.04±0.20)μg/mL](t=2.028,2.118,2.368,2.523,P=0.048,0.037,0.028,0.016);The incidence of adverse reactions in the observation group(8.00%)was lower than that of the control group(24.00%)(χ^2 =4.762,P=0.029).Conclusion The combination of aspirin and ticagrelor is effective in the treatment of AMI.It can not only improve the cardiac function and coagulation function of patients,but also reduce the adverse reactions.