血液透析患者微量元素与细胞免疫功能的关系

Relationship between trace elements and cellular immune function in hemodialysis patients

目的测定血液透析患者的微量元素含量及细胞免疫状态,并评估两者之间的关系。方法选取我院收治的维持性血液透析患者60例,并于同期随机选取30例体检健康者作为对照组。采集两组基础资料,并检测外周血微量元素锌、铜、硒和铁浓度及T细胞亚群分布,两组间进行比较,并分析各微量元素与T细胞亚群之间的相关性。结果血液透析患者的白蛋白和血红蛋白水平均较低,且血浆锌、铁和硒浓度均比健康人群低,但血浆铜水平上升。CD3+、CD4+T淋巴细胞及CD4+/CD8+也降低(P均<0.05)。CD4+T淋巴细胞与血浆锌、硒、铁浓度呈正相关,CD8+T淋巴细胞与血浆锌、硒浓度也呈正相关,但血浆铜水平与CD4+、CD8+T淋巴细胞均无相关性(P>0.05)。结论透析患者存在必需微量元素失衡及T淋巴细胞相关免疫调节明显降低,且两者之间存在一定相关性。

Objective To determine the content of trace elements and cellular immune status in hemodialysis patients,and to evaluate the relationship between the two.Methods 60 patients receiving maintenance hemodialysis in our hospital were selected.At the same time,30 healthy subjects were selected randomly as the control group.The basic data of both groups were collected,and the concentrations of trace elements such as zinc,copper,selenium and iron in peripheral blood and the distribution of T cell subsets were detected.The comparison was made between the two groups,and the correlation between each trace element and the T cell subgroup was analyzed.Results The levels of albumin and hemoglobin were lower in hemodialysis patients,and the concentrations of zinc,iron and selenium in plasma were lower than those in healthy subjects,but plasma copper levels were higher in hemodialysis patients.CD3+,CD4+T lymphocytes,and CD4+/CD8+lymphocytes were also decreased(all P<0.05).CD4+T lymphocytes were positively correlated with plasma zinc,selenium,and iron concentrations.CD8+T lymphocytes were also positively correlated with plasma zinc and selenium concentrations.However,there was no correlation between plasma copper levels and CD4+and CD8+T lymphocytes(P>0.05).Conclusion There is an imbalance of essential trace elements and the T lymphocyte-associated immune regulation is significantly reduced in dialysis patients,and there is a certain correlation between the two.