交感神经去除术在肺动脉高压治疗中的研究进展

Sympathetic Denervation in Treatment of Pulmonary Hypertension

肺动脉高压是一种复杂的临床综合征,虽然在心肺血管疾病中发病率不高,但因其严重影响患者生活质量,致死风险高,被称为心血管疾病中的恶性疾病。靶向药物治疗使得肺动脉高压病情得到一定程度控制,但整体控制率仍不容乐观。随着肺动脉高压相关研究的推进,目前认为交感神经的过度激活在肺动脉高压的发生和维持中起到一定作用,且基于调节自主神经活性的药物和器械治疗在肺动脉高压中的研究得到了一些发现。现就交感神经在肺动脉高压发生和发展的作用、肺动脉神经分布特点和交感神经活性调节的非药物治疗研究进行综述,以探讨肺动脉高压治疗的新思路。

Pulmonary hypertension is a complex clinical syndrome.Though it has the low morbidity,it is regarded as the malignant disease among the cardiovascular diseases due to its high risk of mortality and serious influence on the life quality of patients.Targeted medicine treatment makes the disease controlled somehow,but it’s not satisfying.As the relative studies advanced,researchers pointed out that the overactivation of sympathetic nerve plays a role in the occurrence and maintenance of pulmonary hypertension.Moreover,exciting findings were noted in the research of the pulmonary hypertension treatment by drug and device modulating the autonomic nerve activities.This paper reviews the function of sympathetic nerve in the pulmonary hypertension development,the characters of pulmonary artery nerve distribution and the non-drug treatment research of sympathetic nerve activity modulation,for exploring the new treatment perspective of pulmonary hypertension.