白介素-12家族在冠状动脉粥样硬化中的研究进展

Interleukin-12 Family in Coronary Atherosclerosis

近年来研究发现炎症的持续性和免疫应答失衡在动脉粥样硬化的发生和发展中起到关键作用。多种炎症细胞及其分泌的细胞因子参与到冠状动脉粥样硬化的过程中。而白介素(IL)-12家族作为重要的炎症细胞因子,其家族成员包括IL-12、IL-23、IL-27、IL-35、IL-39和IL-Y,在冠心病的疾病过程中产生的促进或抑制作用已成为近年来国内外心血管领域的研究热点。现主要阐述IL-12家族各细胞因子对冠状动脉粥样硬化作用的研究现状,可能为冠心病的病情评估和治疗提供新的思路。

In recent years,the persistence of inflammation and the imbalance of immune response have been found to play a key role in the occurrence and development of atherosclerosis.Many inflammatory cells and their secreted cytokines are involved in the process of coronary atherosclerosis.Interleukin(IL)-12 family is as inflammatory cell factor,and the family members include IL-12,IL-23,IL-27,IL-35,IL-39 and IL-Y.The promoting or inhibiting effect produced in the process of coronary heart disease has been a hotspot in the cardiovascular research field in recent years.This article mainly describes the current understanding of the role of IL-12 family cytokines in coronary atherosclerosis,which may provide new ideas for the evaluation and treatment of coronary heart disease.