乌司他丁联合腹腔穿刺引流治疗重症急性胰腺炎的效果及对患者炎性因子的影响

Effect of ulinastatin combined with abdominal puncture drainage on severe acute pancreatitis and its influence on inflammatory factors of patients

目的探究乌司他丁联合腹腔穿刺引流治疗重症急性胰腺炎的效果及对患者炎性因子的影响。方法选择2016年8月至2019年8月我院收治的重症急性胰腺炎患者76例为研究对象,随机将其分为两组,各38例。对照组给予腹腔穿刺引流,研究组在对照组的基础上给予乌司他丁治疗。比较两组患者的治疗效果。结果研究组的治疗总有效率显著高于对照组(P<0.05)。研究组的血淀粉酶、尿淀粉酶、胃功能恢复时间均短于对照组(P<0.05)。治疗前,两组的血清IL-6、TNF-α、TXA2和PGI2水平无显著差异(P>0.05);治疗后,两组的血清IL-6、TNF-α、TXA2水平均显著降低,PGI2水平均显著升高,且研究组优于对照组(P<0.05)。结论乌司他丁联合腹腔穿刺引流治疗重症急性胰腺炎的效果较好,可显著缩短患者的临床指标恢复时间,改善炎性因子水平及血管内皮功能,值得临床广泛应用。

Objective To investigate the effect of ulinastatin combined with abdominal puncture drainage on severe acute pancreatitis and its influence on inflammatory factors of patients. Methods A total of 76 patients with severe acute pancreatitis admitted in our hospital from August 2016 to August 2019 were selected as study objects and randomly divided into two groups, with 38 cases in each group. The control group was given abdominal puncture drainage, and the study group was given ulinastatin on the basis of the control group. The treatment effects of the two groups were compared. Results The total effective rate of treatment in the study group was significantly higher than that in the control group(P <0.05). The recovery times of blood amylase, urinary amylase and gastric function in the study group were shorter than those in the control group(P<0.05). Before treatment, there were no significant differences in the levels of serum IL-6, TNF-α, TXA2 and PGI2 between the two groups(P >0.05);after treatment, the levels of serum IL-6, TNF-α, TXA2 in both groups significantly reduced, and PGI2 levels significantly increased, and those in the study group were better than the control group(P<0.05). Conclusion Ulinastatin combined with abdominal puncture drainage has a better effect in the treatments of severe acute pancreatitis, it can significantly shorten the recovery time of clinical indexes of patients, improve the levels of inflammatory factors and vascular endothelial function, which is worthy of clinical widely application.