血府逐瘀胶囊联合阿托伐他汀钙片治疗气滞血瘀型高脂血症的效果

Effect of Xuefu Zhuyu Capsules combined with Atorvastatin Calcium Tablets in the treatment of hyperlipidemia of Qi stagnation and blood stasis type

目的探讨血府逐瘀胶囊联合阿托伐他汀钙片治疗气滞血瘀型高脂血症的效果。方法选取我院神经内科门诊2017年1月~2019年11月诊治的96例气滞血瘀型原发性高脂血症患者作为研究对象,按照随机数字表法分为对照组(48例)与观察组(48例)。两组患者均进行饮食指导和生活方式调节,对照组患者给予阿托伐他汀钙片口服,观察组患者在对照组治疗的基础上给予血府逐瘀胶囊口囊。两组均治疗2个月。比较两组患者的治疗效果、不良反应发生率以及治疗前、治疗2个月后的血脂水平和中医症候水平。结果观察组的总有效率为95.83%,高于对照组的75.00%,差异有统计学意义(P<0.05)。两组治疗2个月后的总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平低于治疗前,且观察组治疗2个月后的高密度脂蛋白胆固醇(HDL-C)水平高于治疗前,差异均有统计学意义(P<0.05)。观察组治疗2个月后的TC、TG、LDL-C水平低于对照组,而HDL-C水平高于对照组,差异有统计学意义(P<0.05)。两组治疗2个月后的中医症候评分低于治疗前,且观察组2个月治疗后的中医症候评分低于对照组,差异均有统计学意义(P<0.05)。两组治疗过程中的不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用血府逐瘀胶囊联合阿托伐他汀钙片对气滞血瘀型高脂血症患者进行治疗,能够取得良好的临床效果,可以有效改善患者的血脂指标及中医症候,且不增加不良反应,值得在临床上推广应用。

Objective To explore the effect of Xuefu Zhuyu Capsules combined with Atorvastatin Calcium tablets in the treatment of hyperlipidemia of Qi stagnation and blood stasis type.Methods A total of 96 patients with primary hyperlipidemia of Qi stagnation and blood stasis type diagnosed and treated in the department of Neurology clinic of our hospital from January 2017 to November 2019 were selected as the research objects,and they were divided into the control group(48 cases)and the observation group(48 cases)according to the method of random number table methods.Both groups were given diet guidance and lifestyle adjustment.Patients in the control group were given Atorvastatin Calcium tablets orally,The patients in the observation group were given Xuefu Zhuyu Capsules oral capsule on the basis of the treatment in the control group.Both groups were treated for 2 months.The therapeutic effect,the incidence of adverse reactions,the level of blood lipid and the level of traditional Chinese medicine syndrome symptoms before and after treatment of two months were compared between the two groups.Results The total effective rate of the observation group was 95.83%,which was higher than that of the control group(75.00%),the difference was statistically significant(P<0.05).The levels of total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)in the two groups after treatment of two months were lower than those before treatment,and the high density lipoprotein cholesterol(HDL-C)level in the observation group after treatment of two months was higher than that before treatment,the difference was statistically significant(P<0.05).The level of TC,TG and LDL-C in the observation group after treatment of two months were lower than those in the control group,while the level of HDL-C in the observation group after treatment of two months was higher than that in the control group,the difference was statistically significant(P<0.05).The traditional Chinese medicine symptom scores of the two groups after treatment of two months were lower than before treatment,and the score of traditional Chinese medicine symptoms in the observation group after treatment of two months was lower than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The treatment of hyperlipidemia patients of Qi stagnation and blood stasis type with Xuefu Zhuyu Capsules combined with Atorvastatin Calcium Tablets can achieve good clinical effect,which can effectively improve the blood lipid index and traditional Chinese medicine symptoms of patients,and does not increase adverse reactions,it is worthy of clinical promotion and application.