宫颈癌组织诱捕受体3在宫颈病变中的表达水平与高危型人乳头瘤病毒感染的相关性研究

Correlation between the expression level of expression of Decoy receptor 3 in cervical lesions and high-risk human papillomavirus infection

目的探讨宫颈癌组织诱捕受体3(DcR3)在宫颈病变中的表达水平与高危型人乳头瘤病毒(HR-HPV)感染的相关性。方法回顾性分析2017年1月~2018年6月我院收治的80例宫颈癌及宫颈上皮内瘤病变(CIN)患者临床资料,经病理学分组分为CINⅠ组16例,CINⅡ组24例,CINⅢ组27例及宫颈癌组13例,比较各组DcR3表达水平,分析各组HR-HPV感染阳性检出率及与癌变程度相关性。结果CINⅠ组HR-HPV阳性检出率为43.75%,CINⅡ组HR-HPV阳性检出率为62.50%,CINⅢ组HR-HPV阳性检出率为88.89%,宫颈癌组HR-HPV阳性检出率92.31%;CINⅠ组DcR3阳性检出率为31.25%,CINⅡ组DcR3阳性检出率为45.83%,CINⅢ组DcR3阳性检出率为66.67%,宫颈癌组DcR3阳性检出率为76.92%。经Spearman分析,CIN严重程度与HR-HPV感染、DcR3表达成正相关(r=0.426、0.324,P<0.05);且DcR3在宫颈病变中表达水平与HR-HPV感染成正相关(r=0.681,P<0.05)。结论高危型HPV感染、DcR3表达与宫颈癌、宫颈上皮内瘤病变成正相关性,即HR-HPV、DcR3阳性率随CIN病变程度升高而升高,且DcR3在宫颈病变中的表达水平与HR-HPV感染成正相关。

Objective To investigate the correlation between the expression of Decoy receptor 3(DcR3)in cervical lesions and high-risk human papillomavirus(HR-HPV)infection.Methods The clinical data of 80 patients with cervical cancer and cervical intraepithelial neoplasia(CIN)from January 2017 to June 2018 were retrospectively analyzed.The pathological group was divided into 16 cases of CINⅠ group and 24 cases of CINⅡ group.For example,27 patients in the CINⅢ group and 13 patients in the cervical cancer group.The expression levels of DcR3 in each group were compared.The positive rate of HR-HPV infection and the correlation with the degree of carcinogenesis were analyzed.Results The positive rate of HR-HPV in CINⅠ group was 43.75%,the positive rate of HR-HPV in CINⅡ group was 62.50%,the positive rate of HR-HPV in CINⅢ group was 88.89%.the positive rate of HR-HPV in cervical cancer group was 92.31%.The positive rate of DcR3 in CINⅠgroup was 31.25%,the positive rate of DcR3 in CINⅡ group was 45.83%,and the positive rate of DcR3 in CINⅢ group was 66.67%,the positive rate of DcR3 was 76.92% in the cervical cancer group.The Spearman analysis showed that the severity of CIN was positively correlated with HR-HPV infection and DcR3 expression(r=0.426,0.324,P<0.05);and the expression level of DcR3 in cervical lesions and HR-HPV infection is positively correlated(r=0.426,0.324,P<0.05).Conclusion The high-risk HPV infection and DcR3 expression are positively correlated with cervical cancer and cervical intraepithelial neoplasia.The positive rate of HR-HPV and DcR3 increases with the degree of CIN lesion,and the expression level of DcR3 in cervical lesions and HR-HPV infection is positively correlated.