子宫内膜息肉切除术联合雌孕激素在子宫内膜息肉患者中的应用

Application of transcervical resection of polyp combined with estrogen and progestin in patients with endometrial polyps

目的探讨子宫内膜息肉切除术(TCRP)联合雌孕激素在子宫内膜息肉(EP)患者中的应用,评价其临床效果。方法选取2016年7月~2018年3月我院收治的106例EP患者作为研究对象,按照随机数字表法分为对照组(n=53)与治疗组(n=53)。对照组采用TCRP方法,治疗组在对照组的基础上采用雌孕激素方法。比较两组子宫内膜厚度、月经失血量、雌孕激素、不良反应发生率及复发情况。结果治疗组术后12个月子宫内膜厚度薄于对照组,月经失血图(PBAC)评分低于对照组,差异均有统计学意义(P<0.05);治疗组术后12个月雌激素水平低于对照组,孕激素水平高于对照组,差异均有统计学意义(P<0.05);两组术前子宫内膜厚度、PBAC评分、雌激素及孕激素水平比较,差异无统计学意义(P>0.05);治疗组经期延长、阴道不规则流血、乳房胀痛的发生率及复发率低于对照组,差异均有统计学意义(P<0.05)。结论TCRP联合雌孕激素治疗EP患者的疗效显著,具有安全可靠,可有效降低子宫内膜厚度,促进月经恢复,减少不良反应及疾病复发,值得借鉴。

Objective To investigate the application of trans-cervical resection of polyps(TCRP)regimen combined with estrogen and progestin in patients with endometrial polyps(EP)and evaluate its clinical effect.Methods A total of 106 patients with EP treated in our hospital from July 2016 to March 2018 were selected as the research subjects.They were divided into control group(n=53)and treatment group(n=53)according to the random number table method.TCRP method was used in the control group.In the treatment group,estrogen and progestin method was added on the basis of the control group.The endometrial thickness,menstrual blood loss,estrogen and progesterone,adverse reactions and recurrence were compared between the two groups.Results The thickness of endometrium at 12 months after surgery in the treatment group was thinner than that in the control group,the pictorial blood loss assessment chart(PBAC)score was lower than that in the control group,and the differences were statistically significant(P<0.05).The estrogen level was lower and the progesterone level in the treatment group was higher compared with those in the control group,the differences were statistically significant(P<0.05).There were no statistical differences in the endometrial thickness,PBAC score,estrogen and progesterone levels of the two groups(P>0.05).The incidence and recurrence rate of prolonged menstrual period,irregular vaginal bleeding,breast distending pain in the treatment group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion TCRP combined with estrogen and progestin is effective in treating patients with EP,and it is safe and reliable.It can effectively reduce the thickness of the endometrium,promote menstrual recovery,and reduces adverse reactions and disease recurrence,which is worthy of reference.