小剂量异维A酸联合2%超分子水杨酸治疗中重度痤疮疗效观察

Clinical Observation of Low-dose Isotretinoin Combined with 2%Supramolecular Salicylic Acid in the Treatment of Moderate to Severe Acne

目的:探讨口服小剂量异维A酸联合外用2%超分子水杨酸治疗中重度痤疮的临床疗效。方法:共选取74例中重度痤疮患者作为研究对象,口服小剂量异维A酸10mg,1次/d。治疗组:37例,联合外用2%新型超分子水杨酸治疗;对照组:37例,联合外用夫西地酸乳膏及阿达帕林凝胶治疗。对两组患者治疗前后的皮损数量变化及治疗效果进行对比分析。结果:经过8周的治疗,两组研究对象的总皮损数量较治疗前均显著减少(P<0.05),且治疗组与对照组比较,无明显差异(P>0.05)。针对不同类型的皮损,治疗组对粉刺的疗效比对照组更具优势,对丘疹与结节的疗效无明显差异。结论:治疗中重度痤疮,小剂量异维A酸联合外用2%超分子水杨酸临床疗效较好,副作用小,可作为痤疮治疗的新选择。

Objective Toobserve the clinical effi cacy of oral low-dose isotretinoin combined with 2%supramolecular salicylic acid in the treatment of moderate and severe acne.Methods A total of 74 patients with moderate to severe acne were included and treated with low-dose isotretinoin(10mg)daily.The treatment group was treated combined with 2%supramolecular salicylic acid,while the control group was treated combined with fusidic acid cream and adapalene gel.The comparative analyses,including the changes in the number of skin lesions and the treatment effect,were conductedbefore and after treatment in the two groups of patients.Results After 8 weeks of treatment,the two groups showed signifi cant improvement compared with thebaseline(P<0.05),but there was no marked difference between the treatment group and the control group(P>0.05).For different types of skin lesions,the effect of the treatment group on acne is more advantageous than the control group,and there is no signifi cant difference in the treatment effect on papules and nodules.Conclusion Low-dose isotretinoincombined with 2%supramolecular salicylic acid is effective in the treatment of moderate to severe acneandhasminor side effects,which is a new option for treatingacne.