脂溶性维生素注射液联合丁二磺酸腺苷蛋氨酸治疗酒精性肝病伴肝内胆汁淤积的临床效果

Clinical effect of Fat-Soluble Vitamin Injection combined with Adenosine Butadionate Methionine in the treatment of alcoholic liver disease with intrahepatic cholestasis

目的评估脂溶性维生素注射液联合丁二磺酸腺苷蛋氨酸治疗酒精性肝病伴肝内胆汁淤积的临床效果。方法回顾性分析2016年12月~2019年3月我院收治的126例酒精性肝病伴肝内胆汁淤积患者的临床资料,按照治疗方法分为对照组(68例)、研究组(58例),对照组采用接受丁二磺酸腺苷蛋氨酸治疗方法,研究组采用脂溶性维生素注射液联合丁二磺酸腺苷蛋氨酸治疗方法。比较两组的近期疗效、肝功能[天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBil)、碱性磷酸酶(ALP)]、凝血功能[凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)]及可溶性黏附分子-1(sVCAM-1)、磷脂转运蛋白(PLTP)水平,药物不良反应发生率情况差异。结果治疗4周后,研究组患者的总有效率高于对照组(χ^2=4.645,P=0.031);研究组患者肝功能指标AST、ALT、TBil、ALP的水平低于对照组(t=15.964、19.451、18.656、9.130,P均<0.05);凝血指标PT、TT、APTT短于对照组,FIB的水平高于对照组(t=3.334、5.520、4.873、6.704,P均<0.05);sVCAM-1、PLTP的水平低于对照组(t=12.543、6.717,P均<0.05)。治疗期间,两组患者药物不良反应总发生率比较,差异无统计学意义(P>0.05)。结论酒精性肝病伴肝内胆汁淤积患者接受脂溶性维生素注射液联合丁二磺酸腺苷蛋氨酸治疗的效果确切、安全性良好。

Objective To evaluate the clinical effect of Fat-Soluble Vitamin Injection combined with Adenosine Butadionate Methionine in the treatment of alcoholic liver disease with intrahepatic cholestasis.Methods Clinical data of 126 cases of alcoholic liver disease with intrahepatic cholestasis patients in our hospital during December 2016 to March 2019 were retrospectively analyzed.According to the treatment methods they were divided into control group(68 cases),observation group(58 cases).Patients in control group were treated with Adenosine Butadionate Methionine,those in study group used Fat-Soluble Vitamin Injection combined with Adenosine Butadionate Methionine treatment.Short-term efficacy,liver functionindexes(glutamic oxaloacetic transaminase[AST],alanine aminotransferase[ALT],total bilirubin[TBil],alkaline phosphatase[ALP]),coagulation indexes(prothrombin time[PT],thrombin time[TT],activated partial thromboplastin time[APTT],fibrinogen[FIB]and thromboplastin function[PT]),soluble adhesion molecule-1(sVCAM-1)and phospholipid transporter(PLTP)were compared between two groups.During treatment period,the incidence of adverse drug reactions were recorded.Results 4 weeks after treatment,the total effective rate in study group was higher than that in control group(χ^2=4.645,P=0.031);levels of AST,ALT,TBil and ALP in study group were lower than those in control group(t=15.964,19.451,18.656,9.130,P<0.05);the PT,TT and APTT in study group were shorer than those in control group,FIB was higher than that in the control group(t=3.334、5.520、4.873、6.704,P<0.05);levels of sVCAM-1 and PLTP in the control group were lower than those in the control group(t=12.543、6.717,P<0.05).During treatment,there was no significant difference in the total incidence of adverse drug reactions between two groups(P>0.05).Conclusion The effect of Fat-Soluble Vitamin Injection combined with Adenosine Butadionate Methionine in patients with alcoholic liver disease and intrahepatic cholestasis is reliable.At the same time,it has good therapeutic safety.