甲基强的松龙治疗在急性期多发性硬化的应用效果

Application effect of Methylprednisolone in the treatment of acute multiple sclerosis

目的分析甲基强的松龙治疗急性期多发性硬化的临床效果及安全性。方法选取本院2018年1月~2019年8月收治的94例急性期多发性硬化患者作为研究对象,按照随机数字表法分为参照组(47例)与研讨组(47例)。参照组采用地塞米松配合甲基强的松龙治疗,地塞米松20 mg与浓度为0.9%氯化钠500 ml溶合并静脉滴注用药5 d,然后每天口服10 mg甲基强的松龙,连续服用90 d。研讨组采用甲基强的松龙治疗,甲基强的松龙1000 mg与浓度为0.9%氯化钠注射液500 ml溶合并静脉滴注用药5 d,然后每天口服60 mg甲基强的松龙,连续服用90 d。比较两组的CD4^+、CD8^+、CD4^+/CD8^+水平及不良反应总发生率。结果两组治疗后的CD4^+水平比较,差异无统计学意义(P>0.05);研讨组治疗后的CD8^+水平高于参照组,差异有统计学意义(P<0.05);两组治疗后的CD4^+/CD8^+水平比较,差异无统计学意义(P>0.05)。研讨组的不良反应总发生率低于参照组,差异有统计学意义(P<0.05)。结论甲基强的松龙应用于急性期多发性硬化的治疗可有效调节T淋巴细胞亚群的平衡,减少患者的不良反应,值得推广。

Objective To analyze the clinical effect and safety of Methylprednisolone in the treatment of acute multiple sclerosis.Methods A total of 94 patients with acute multiple sclerosis admitted to our hospital from January 2018 to August 2019 were selected as the research subjects.They were divided into the reference group(n=47)and the study group(n=47)by the random number table method.Dexamethasone combined with Methylprednisolone treatment was applied in the reference group,20 mg of Dexamethasone dissolved in 500 ml of 0.9%sodium chloride was injected intravenously for 5 days,followed by oral administration of 10 mg of Methylprednisolone daily for 90 days.In the study group,patients were treated with Methylprednisolone,1000 mg of Methylprednisolone dissolved in 500 ml of 0.9%sodium chloride was injected intravenously for 5 days,followed by oral administration of 60 mg of Methylprednisolone daily for 90 days.The levels of CD4^+,CD8^+,CD4^+/CD8^+and the total incidence rate of adverse reaction were compared between the two groups.Results There was no significant difference in the level of CD4^+between the two groups after treatment(P>0.05).The level of CD8^+in the study group after treatment was higher than that of the reference group,and the difference was statistically significant(P<0.05).There was no significant difference in the level of CD4^+/CD8^+between the two groups after treatment(P>0.05).The total incidence rate of adverse reaction in the study group was lower than that of the reference group,and the difference was statistically significant(P<0.05).Conclusion Methylprednisolone applied in the treatment of acute multiple sclerosis can effectively regulate the balance of T lymphocyte subsets and reduce patients′adverse reactions,which is worthy of promotion.