盐酸多奈哌齐联合尼莫地平治疗血管性痴呆的临床效果

Clinical effect of Donepezil Hydrochloride combined with Nimodipine in the treatment of vascular dementia

目的评估盐酸多奈哌齐联合尼莫地平治疗血管性痴呆的临床效果和安全性,为临床医师选择合理用药方案提供参考。方法选取2018年1月~2019年7月沈阳市红十字会医院诊治的86例血管性痴呆患者为研究对象,依据随机数字表法将其分为对照组和试验组,每组43例,对照组给予尼莫地平治疗,试验组采用盐酸多奈哌齐与尼莫地平联合用药方案治疗,比较两组的临床疗效和安全性。结果试验组患者的临床总有效率(93.02%)高于对照组(76.74%),差异有统计学意义(P<0.05);两组治疗前的简易智力状态检查量表(MMSE)评分、日常生活能力(ADL)评分比较,差异无统计学意义(P>0.05),治疗后两组的MMSE评分、ADL评分均高于治疗前,差异有统计学意义(P<0.05),且试验组高于对照组,差异有统计学意义(P<0.05);试验组和对照组的不良反应总发生率比较(9.30%vs.4.65%),差异无统计学意义(P>0.05)。结论在血管性痴呆患者治疗中,采用盐酸多奈哌齐联合尼莫地平用药方案的临床效果显著,能够改善患者认知状态,提高其生活能力,且具有良好的安全性,值得推荐。

Objective To evaluate the clinical effect and safety of Donepezil Hydrochloride combined with Nimodipine in the treatment of vascular dementia,and to provide reference for clinicians to choose a reasonable drug regimen.Methods A total of 86 patients with vascular dementia diagnosed and treated in Shenyang Red Cross Hospital from January 2018 to July 2019 were selected as the study objects.According to the method of random number table,they were divided into control group and experimental group,43 cases in each group.The control group was given Nimodipine treatment.The experimental group was treated with the combination of Donepezil Hydrochloride and Nimodipine.the clinical efficacy and safety of the two groups were compared.Results The total clinical effective rate in the experimental group(93.02%)was higher than that in the control group(76.74%),the difference was statistically significant(P<0.05).There were no significant differences between the two groups in the mini-mental state examination scale(MMSE)score and the ability of daily life(ADL)score before treatment(P>0.05).After treatment,MMSE score and ADL score of the two groups were higher than those before treatment,the differences were statistically significant(P<0.05),and the MMSE score and ADL score of the experimental group were higher than those of the control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions of the experimental group and control group was compared(9.30%vs.4.65%),the difference was not statistically significant(P>0.05).Conclusion In the treatment of vascular dementia patients,the combination of Donepezil Hydrochloride and Nimodipine has significant clinical effect,can improve the cognitive status of patients,improve their living ability,and has good safety,it is worth recommending.