克龄蒙联合艾司西酞普兰治疗围绝经期抑郁症的疗效观察

Curative effect observation of Climen combined with Escitalopram in the treatment of perimenopausal depression

目的探讨戊酸雌二醇片/雌二醇环丙孕酮片复合包装联合艾司西酞普兰在围绝经期抑郁症治疗中的应用。方法选取赣州市第三人民医院2016年1月~2017年12月收治的60例围绝经期抑郁症患者作为研究对象,按照随机数字表法分为研究组(30例)与对照组(30例)。研究组采用戊酸雌二醇片/雌二醇环丙孕酮片复合包装+艾司西酞普兰治疗,对照组采用艾司西酞普兰治疗。比较两组的汉密尔顿抑郁量表评分(HAMD)、治疗效果及不良反应发生情况。结果研究组治疗后第4、8、12周的HAMD评分均低于对照组,差异有统计学意义(P<0.05);研究组的治疗总有效率高于对照组,差异有统计学意义(P<0.05);研究组的不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论戊酸雌二醇片/雌二醇环丙孕酮片复合包装联合艾司西酞普兰在治疗围绝经期抑郁症中的应用效果显著,能降低患者抑郁状况,提升治疗效果,且具有较低不良反应发生率。

Objective To explore the application of Estradiol Valproate Tablets/Escitalopram Tablets and Escitalopram in the treatment of perimenopausal depression.Methods A total of 60 patients with perimenopausal depression in Ganzhou Third People′s Hospital from January 2016 to December 2017 were selected as the subjects of the study.According to the random number table method,the patients were divided into the study group(30 cases)and the control group(30 cases).The study group was treated with Estradiol Valproate Tablets/Escitalopram Tablets+Escitalopram Tablets,while the control group was treated with Escitalopram.The Hamilton depression scale(HAMD),therapeutic effect and adverse reactions were compared between the two groups.Results The HAMD scores of the study group at the 4th,8th and 12th weeks after treatment were lower than those of the control group,the differences were statistically significant(P<0.05).The total effective rate of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Estradiol Valerate Tablets/Escitalopram Tablets combined with Escitalopram are effective in the treatment of permenopausal depression,which can reduce the depression status of patients,improve the therapeutic effect,and have a lower incidence of adverse reactions.