化痰调经汤联合西药治疗在多囊卵巢综合征 肾虚痰湿证患者中的应用效果

Application effect of Huatan Tiaojing Decoction combined with Western medicine therapy in polycystic ovary syndrome with kidney deficiency and phlegm-dampness syndrome

目的探讨化痰调经汤联合西药治疗在多囊卵巢综合征(PCOS)肾虚痰湿证患者中的应用效果。方法选取2018年3月~2019年6月就诊于我院的70例PCOS患者,按随机数字表法分为两组,各35例。对照组使用炔雌醇环丙孕酮片治疗,试验组在此基础上口服化痰调经汤治疗。比较两组临床疗效、中医证候积分、性激素水平及不良反应发生情况。结果试验组治疗总有效率为94.29%,高于对照组的74.29%,差异有统计学意义(P<0.05);试验组中医证候积分为(4.13±1.21)分,低于对照组的(8.36±2.27)分,差异有统计学意义(P<0.05);两组治疗后促卵泡生成激素(FSH)水平比较,差异无统计学意义(P>0.05);试验组雌二醇(E2)水平高于对照组,黄体生成素(LH)、睾酮(T)水平低于对照组,差异有统计学意义(P<0.05);两组治疗期间均未出现明显不良反应。结论PCOS患者口服化痰调经汤联合西药治疗安全性较高,能有效改善患者临床症状与体征,调节激素水平,利于促进病情恢复,值得临床推广。

Objective To investigate the application effect of Huatan Tiaojing Decoction combined with Western medicine therapy in polycystic ovary syndrome(PCOS)with kidney deficiency and phlegm-dampness syndrome.Methods A total of 70 patients with PCOS who visited our hospital from March 2017 to June 2019 were divided into two groups according to random number table method,35 cases in each group.The control group was treated with Ethinylestradiol Cyproterone Tablets,and the test group was treated with Huatan Tiaojing Decoction based on the control group.The clinical effect,sex hormone level,polycystic change of ovary and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the experimental group was 94.29%,which was higher than that of control group(74.29%),the difference was statistically significant(P<0.05).The traditional Chinese medicine score of the experimental group was(4.13±1.21)points,which was lower than that of the control group for(8.36±2.27)points(P<0.05).There was no significant difference in the level of follicle stimulating hormone(FSH)between the two groups after treatment(P>0.05).The level of estradiol(E2)in the experimental group was higher than that in the control group,while the levels of luteinizing hormone(LH)and testosterone(T)in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).No significant adverse reactions were observed in the two groups.Conclusion The treatment of PCOS patients with oral Huatan Tiaojing Decoction combined with Western medicine is safe,can effectively improve the clinical symptoms and signs of patients,regulate hormone levels,promote the recovery of the disease,it is worth clinical promotion.