围绝经期妇女血清雌二醇水平与胆固醇、三酰甘油水平的关联性分析

Correlation analysis of serum estradiol level with total cholesterol and triglyceride level in perimenopausal women

目的探讨血清雌二醇(E2)、总胆固醇(TC)及三酰甘油(TG)水平在围绝经期妇女中的表达及临床意义。方法选择江西省新余第四医院2019年1~7月收治的125例围绝经期女性作为观察组,选择同期的在江西省新余第四医院体检的100名健康女性作为对照组,比较两组的E2、TC、TG水平,并分析E2与TC、TG的相关性。结果观察组的E2水平为(54.7±9.5)ng/L,低于对照组的(97.8±10.6)ng/L,差异有统计学意义(P<0.05)。观察组的TC水平为(5.4±0.6)mmol/L,TG水平为(1.2±0.4)mmol/L,均高于对照组的(4.8±0.7)、(0.9±0.5)mmol/L,差异有统计学意义(P<0.05)。E2与TC、TG水平成负相关(r=-0.812、-0.513,P<0.05)。结论围绝经期妇女E2水平与TC、TG水平呈现明显负相关,可以为指导临床治疗提供依据。

Objective To explore the expression and clinical significance of serum estradiol(E2),total cholesterol(TC)and triacylglycerol(TG)in perimenopausal women.Methods A total of 125 perimenopausal women admitted to the Fourth Hospital of Xinyu City in Jiangxi Province from January to July in 2019 were selected as the observation group,and 100 healthy women who had physical examination in the Fourth Hospital of Xinyu City in Jiangxi Province in the same period were selected as the control group.The levels of E2,TC and TG were compared between the two groups,and the correlation between E2 and TC,TG was analyzed.Results The E2 level of the observation group was(54.7±9.5)ng/L,which was lower than that of the control group([97.8±10.6]ng/L),the difference was statistically significant(P<0.05).The level of TC of the observation group was(5.4±0.6)mmol/L,the level of TG of the observation group was(1.2±0.4)mmol/L,which were higher than those of the control group([4.8±0.7],[0.9±0.5]mmol/L),the differences were statistically significant(P<0.05).The level of E2 and TC、TG were significant negative correlation(r=-0.812,-0.513,P<0.05).Conclusion The E2 level and TC,TG levels of women in perimenopause are significant negative correlation,which could provide basis for guiding clinical treatment.