左心室射血分数降低型心力衰竭患者血清半乳糖凝集素-3水平与碎裂QRS波的相关性分析

Correlation between Serum Galectin-3 Levels and Fragmented QRS in Heart Failure Patients with Reduced Left Ventricular Ejection Fraction

目的探讨左心室射血分数(LVEF)降低型心力衰竭(HF)患者血清半乳糖凝集素-3(galectin-3)水平与心电图碎裂QRS波(fragmented QRS,fQRS)之间的相关性。方法回顾性分析2014-2018年宝鸡市人民医院收治的439例LVEF降低型HF患者的临床资料,通过Logistics回归分析确定影响fQRS波发生的独立危险因素,采用受试者工作特征曲线(ROC)分析血清galectin-3水平对fQRS波的诊断价值。结果 439例LVEF降低型HF患者,出现fQRS波143例(fQRS波组),占32.6%;无fQRS波296例(非fQRS波组),占67.4%。与非fQRS波组相比,fQRS波组血清Galectin-3、NT-proBNP水平均显著升高(P<0.001)。多因素Logistics回归分析显示血清Galectin-3水平是影响fQRS波发展的独立危险因素(OR=1.231,95%CI:1.076~1.375,P=0.001)。ROC曲线分析显示血清galectin-3水平对fQRS波的诊断价值为0.812(P<0.001),其诊断阈值为538.5 pg·mL^-1,灵敏度为78.5%、特异度为76.8%。结论 LVEF降低型HF患者心电图fQRS波与血清galectin-3水平相关,血清galectin-3水平升高能够预测fQRS波的存在。

Objective To investigate the correlation between serum galectin-3 levels and fragmented QRS(fQRS) in heart failure(HF) patients with reduced left ventricular ejection fraction(LVEF).Methods A retrospective analysis was carried out on 439 patients with LVEF-reduced HF who were admitted in our hospital between 2014 and 2018.The independent risk factors for fQRS were analyzed by logistic regression analysis.The diagnostic value of serum galectin-3 levels for fQRS was evaluated using the receiver operating characteristic(ROC) curve analysis.ResultsAmong the 439 patients,143(32.6%) had fQRS,and 296(67.4%) had no fQRS.The serum levels of galectin-3 and NT-proBNP in patients with fQRS were higher than those in patients without fQRS(P<0.001).Multivariate logistic regression analysis showed that serum galectin-3 levels were the independent risk factor for fQRS(OR=1.231,95%CI: 1.076-1.375,P=0.001).ROC curve analysis showed that the diagnostic value of galectin-3 for fQRS was 0.812(P<0.001),with a cut-off value of 538.5 pg·mL^-1,a sensitivity of 78.5% and a specificity of 76.8%.ConclusionSerum galectin-3 levels are positively correlated with fQRS in patients with LVEF-reduced HF.The elevated galectin-3 levels can predict the presence of fQRS.