推动体外器官灌注技术发展,提高捐献器官利用率及质量

Advancing extracorporeal organ perfusion technology and improving the utilization and quality of donor organs

器官移植是目前治疗终末期器官衰竭唯一有效的方法,供器官来源短缺严重阻碍器官移植的发展。提高边缘供者供器官使用率可部分缓解器官来源短缺现状。随着器官保存技术的不断发展,机械灌注逐渐成为提高供器官质量的重要研究方向。机械灌注有望成为优于传统静态冷保存的器官保存技术,可改善体外供器官保存环境并提供供器官质量评估体系,更好地修复边缘供者供器官,提高供器官利用率。本文概述器官保存技术的发展历程、研究进展和未来趋势,通过医工融合,共同推动机械灌注技术发展,提高捐献器官质量及利用率。

Organ transplantation is the only effective treatment for end-stage diseases,and the scarcity of donor organ seriously hinders the development of organ transplantation.Increasing the utilization rate of marginal organs can partially alleviate the shortage of organs.With the continuous development of organ preservation technology,machine perfusion has gradually become an crucial research direction to improve the quality of donor organs.Machine perfusion is expected to be superior organ preservation technology than static cold storage and improves preservation environment and quality assessment system of the isolated donor organ,repairs marginal donor organs and improves organ utilization.We review the research progress of machine perfusion technology and the future development,through the fusion of medicine and engineering,the development of machine perfusion technology will improve the quality and utilization rate of donor organs.