超声剪切波组织定量技术在IgA肾病牛津分型中的应用

Application of Elasto Point Quantification in Oxford Classification of IgA Nephropathy

目的:探讨超声剪切波组织定量技术(Elasto PQ)在IgA肾病(IgAN)牛津分型中的应用价值。方法:收集IgAN患者65例,运用彩色超声诊断仪,通过测量肾脏中部皮质的弹性获得杨氏模量值,入组患者同时行肾脏穿刺活检术进行病理学检查;采用t检验及单因素方差分析对收集到的IgAN牛津分型中各项病理改变组间的杨氏模量值进行统计学分析。结果:IgAN牛津分型中系膜细胞增生(M)、毛细血管内细胞增生(E)及节段性硬化或黏连(S)组间差异无统计学意义(P>0.05);在肾小管萎缩或肾间质纤维化(T)的病理改变中,T1、T2组患者的杨氏模量值较T0组升高,差异有统计学意义(P<0.05),T1与T2组间差异无统计学意义(P>0.05)。结论:杨氏模量值能够区分IgAN牛津分型中肾脏组织的T病变。

Objective:To investigate the application value of Elasto point quantification(Elasto PQ)in the Oxford classification of IgA nephropathy.Methods:The data were collected from 65 cases with IgA nephropathy(IgAN).With the use of color ultrasonic diagnostic apparatus,Young's modulus value was captured by measuring the elasticity of the middle cortex of the kidney.All patients received pathological examination of renal biopsy.Statistical analysis of Young's modulus taken from all groups with pathological changes in IgAN oxfords classification was made through t test and one-way ANOVA.Results:In the four Oxford types of IgAN,there was no statistically significant difference between the pathological changes in mesangial hypercellularity(M),endocapillary hypercellularity(E),segmental sclerosis or adhesion(S)(P>0.05).In the pathological changes of renal tubular atrophy or renal interstitial fibrosis(T),the Young's modulus value of T1 and T2 groups was higher than that of T0 group,and the difference was statistically significant(P<0.05),while there was no statistical difference between T1 group and T2 group(P>0.05).Conclusion:Young's modulus is able to distinguish the presence or absence of T lesions in the Oxford types of IgAN.