血清维生素A及维生素E水平与孕期子痫前期的相关性

Correlation between Serum Vitamin A and Vitamin E Levels and Preeclampsia during Pregnancy

目的:探讨血清维生素A、维生素E水平与孕期子痫前期的相关性。方法:选取70例子痫前期孕妇作为研究组,其中38例轻度子痫前期的妊娠妇女作为轻度组、32例重度子痫前期作为重度组,122例正常妊娠妇女作为对照组;比较3组孕妇孕20周时的血清维生素A及维生素E水平,子痫前期两组于孕20周开始治疗5周,比较子痫前期两组治疗前后血清维生素A及维生素E水平,采用Spearman秩相关分析孕20周时研究组患者血清维生素A及维生素E水平与子痫前期发病相关性;分析维生素A及维生素E水平与子痫前期孕妇年龄、BMI、收缩压、舒张压、尿蛋白及肝酶的关系。结果:3组孕妇维生素A及维生素E水平比较,对照组>轻度组>重度组,差异有统计学意义(P<0.05);Spearman秩相关分析结果显示血清维生素A水平(r=-0.624,P<0.001)及维生素E水平(r=-1.305,P=<0.001)与子痫前期发病呈负相关关系;不同BMI水平及尿蛋白含量与血清维生素A水平有关(P<0.05),不同BMI、收缩压、舒张压、尿蛋白与维生素E水平有关(P<0.05);与治疗前比较,治疗后子痫前期患者血清维生素A及维生素E水平均明显升高(P<0.05)。结论:维生素A、维生素E水平与子痫前期发病呈负相关,治疗后其水平可恢复。

Objective:To explore the correlation between serum vitamin A and vitamin E levels and preeclampsia during pregnancy.Methods:70 preeclampsia pregnant women were selected as the study group,of which 38 pregnant women with mild preeclampsia were treated as mild group,32 severe preeclampsia as severe group,and 122 normal pregnant women as control group.The serum vitamin A and vitamin E were compared in 3 groups at 20 weeks of gestation,and the treatment of preeclampsia began at 20 weeks.To compare the serum vitamin A and vitamin E levels before and after preeclampsia treatment,the correlation between serum vitamin A and vitamin E levels and preeclampsia was analyzed by Spearman rank correlation analysis.The relationship between vitamin A and vitamin E level and age,BMI、systolic blood pressure,diastolic blood pressure,urinary protein and liver enzyme in preeclampsia pregnant women was analyzed.Results:The levels of vitamin A and vitamin E in 3 groups of pregnant women were compared,control group>mild group>severe group,and the difference was statistically significant(P<0.05).Spearman rank correlation analysis showed that serum vitamin A levels(r=-0.624,P<0.001)and vitamin E levels(r=-1.305,P<0.001)were negatively correlated with preeclampsia.The levels of different BMI and urine protein were related to the level of serum vitamin A(P<0.05).Different BMI,systolic pressure,diastolic pressure and urinary protein were related to the level of vitamin E(P<0.05).The levels of serum vitamin A and vitamin E in.Conclusion:The levels of vitamin A and vitamin E are negatively correlated with preeclampsia,and their levels recover after treatment.