颅内动脉瘤栓塞术后并发脑血栓与D-二聚体相关性研究

Correlation between the Cerebral Thrombosis and D-dimer after Intracranial Aneurysm Embolization

目的:分析颅内动脉瘤栓塞术后并发脑血栓与D-二聚体(D-D)的相关性。方法:选取2018年10月-2019年11月本院60例颅内动脉瘤栓塞术后并发脑血栓患者为A组,60例颅内动脉瘤栓塞术后未并发脑血栓患者为B组,另选取同时期60例健康体检者为C组。比较三组的血小板计数(PLT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fg)及D-D水平;比较A、B组术后1、3 d的PLT、PT、APTT、TT、Fg及D-D水平;分析颅内动脉瘤栓塞术后并发脑血栓与D-D的相关性及D-D在术后并发脑血栓中的预测价值。结果:A组PLT、PT、APTT、TT、Fg及D-D水平均高于B组及C组,且B组各指标均高于C组(P<0.05);A组术后1、3 d的PLT、PT、APTT、TT、Fg及D-D水平均高于B组(P<0.05);术后1 d的D-D水平与颅内动脉瘤栓塞术后并发脑血栓呈正相关(r=0.873,P<0.05);D-D预测术后脑血栓发生的ROC曲线下面积为0.802(P=0.005),截断点为1.72 μg/mL,灵敏度为83.30%,特异度为62.40%。结论:颅内动脉瘤栓塞术后并发脑血栓与D-D密切相关,D-D对颅内动脉瘤栓塞术后并发脑血栓的预测价值较高。

Objective:To analyze the correlation between the cerebral thrombosis and D-dimer (D-D) after intracranial aneurysm embolization.Method:A total of 60 patients complicated with cerebral thrombus after intracranial aneurysm embolization in our hospital from October 2018 to November 2019 were selected as group A,60 patients without complicated cerebral thrombus after intracranial aneurysm embolization were selected as group B,and another 60 healthy patients during the same period were selected as group C.Platelet count (PLT),prothrombin time (PT),activated partial thromboplastin time (APTT),thrombin time (TT),fibrinogen (Fg) and D-D levels of the three groups were compared.PLT,PT,APTT,TT,Fg and D-D levels of group A and B were compared on 1 d and3 d after surgery.The correlation between D-D and cerebral thrombus after intracranial aneurysm embolization and the predictive value of D-D in postoperative cerebral thrombus were analyzed.Result:The levels of PLT,PT,APTT,TT,Fg and D-D in group A were higher than those in group B and C,and all indicators in group B were higher than those in group C (P<0.05).The levels of PLT,PT,APTT,TT,Fg and D-D on 1 d and 3 d after surgery in group A were higher than those in group B (P<0.05).The D-D level on 1 d after surgery was positively correlated with cerebral thromboembolism after intracranial aneurysm embolization (r=0.873,P<0.05).The area under the ROC curve predicted by D-D was 0.802 (P=0.005),the cut-off point was 1.72 μg/mL,the sensitivity was 83.30% and the specificity was 62.40%.Conclusion:The correlation between the cerebral thrombosis and D-D after intracranial aneurysm embolization is closed,and D-D has a high predictive value for cerebral thrombus after intracranial aneurysm embolization.