右佐匹克隆与阿普唑仑对睡眠障碍患者睡眠监测参数的影响

Comparison of Effects of Eszopiclone and Alprazolam on Sleep Monitoring Parameters in Patients with Sleep Disorder

目的:分析右佐匹克隆与阿普唑仑对睡眠障碍患者睡眠监测参数的影响。方法:选取2017年1月-2018年12月东莞市第七人民医院收治的80例睡眠障碍患者作为研究对象,借助双盲随机抽样法分为对照组和研究组,各40例。对照组给予阿普唑仑治疗,研究组给予右佐匹克隆治疗。对比两组睡眠监测参数、匹兹堡睡眠质量指数评分(PSQI)、临床效果、不良反应发生率。结果:治疗前,两组睡眠监测参数指标比较,差异均无统计学意义(P>0.05)。治疗第4周末,研究组睡眠监测参数ATA、AT、RL、S2均低于对照组,SE、S1、S3+S4及REM均高于对照组,差异均有统计学意义(P<0.05)。两组治疗前PSQI各因子评分及总分比较,差异均无统计学意义(P>0.05)。研究组治疗第4周末睡眠质量、入睡时间、催眠药物、睡眠时间、睡眠效率、睡眠障碍、日间功能及PSQI总评分较对照组均降低(P<0.05)。治疗第4周末,研究组总有效率为97.50%,高于对照组的87.50%,但差异无统计学意义(P>0.05)。治疗第4周末,研究组不良反应发生率为4.08%,较对照组的20.40%低,差异有统计学意义(P<0.05)。结论:失眠患者给予右佐匹克隆治疗具有明显的优势,可改善睡眠质量,明显提升临床效果,减少不良反应,值得推广与借鉴。

Objective:To analyze the effects of Eszopiclone and Alprazolam on sleep monitoring parameters in patients with sleep disorder.Method:A total of 80 patients with sleep disorder treated in the Seventh People’s Hospital of Dongguan from January 2017 to December 2018 were selected as the subjects,they were divided into the control group and the study group by double-blind random sampling,40 cases in each group.The sleep monitoring parameters,the Pittsburgh Sleep Quality Index(PSQI),the clinical effect and the incidence of adverse reactions of two groups were compared.Result:Before treatment,there was no significant difference in sleep monitoring parameters between the two groups(P>0.05).On the 4th weekend of treatment,the sleep monitoring parameters ATA,AT,RL,S2 in the study group were lower than the control group,the SE,S1,S3+S4 and REM were higher than those of control group,the differences were statistically significant(P<0.05).There were no significant differences between two groups in PSQI each factor score and total score before treatment(P>0.05).On the 4th weekend of treatment,the total scores of sleep quality,sleep time,hypnotic drugs,sleep time,sleep efficiency,sleep disturbance,daytime function and PSQI in the study group were lower than those of control group(P<0.05).At the 4th weekend of treatment,the total effective rate in the study group was 97.50%,which was higher than 87.50%in the control group,but the difference was not statistically significant(P>0.05).At the 4th weekend of treatment,the incidence of adverse reactions in the study group was 4.08%,which was lower than 20.40%in the control group,the difference was statistically significant(P<0.05).Conclusion:The treatment of Eszopiclone in insomnia patients has obvious advantages,which can improve the sleep quality and the clinical effect,reduce the adverse reactions,it is worth of popularizing.