调节阴道菌群对宫颈HPV感染临床治疗效果的影响

Influences of Regulating Vaginal Flora on Clinical Curative Effect of Cervical HPV Infection

目的:探讨调节阴道菌群对宫颈人乳头瘤病毒(HPV)感染临床治疗效果的影响。方法:选取2019年1-4月于本院就诊的114例宫颈HPV感染患者,根据随机数字表法将其分为对照组和观察组,每组57例。对照组采用常规对症治疗,观察组在对照组基础上予以乳酸杆菌治疗。比较两组的治疗效果、治疗3、6个月后HPV转阴率、治疗前后阴道分泌物pH值及不良反应发生率。结果:观察组治疗总有效率为87.72%,显著高于对照组的71.93%,差异有统计学意义(P<0.05)。观察组治疗3、6个月后的HPV转阴率均高于对照组治疗3、6个月后的HPV转阴率,差异均有统计学意义(P<0.05)。治疗后,两组阴道分泌物pH值均低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。观察组的不良反应发生率为5.26%,低于对照组的14.04%,差异无统计学意义(P>0.05)。结论:使用乳酸杆菌调节阴道菌群治疗宫颈HPV感染疗效确切,能显著提高HPV转阴率,有利于阴道微生态恢复。

Objective:To investigate the influences of regulating vaginal flora on the clinical treatment of cervical human papillomavirus(HPV)infection.Method:A total of 114 patients with cervical HPV infection who visited our hospital from January to April 2019 were selected.According to the random number table method,they were divided into control group and observation group,57 cases in each group.The control group received conventional symptomatic treatment,the observation group was treated with lactobacillus on the basis of the control group.The two groups were compared in terms of treatment effect,the negative rate of HPV after 3 and 6 months of treatment,the pH value of vaginal secretions before and after treatment,and the incidence of adverse reactions.Result:The total effective rate of the observation group was 87.72%,significantly higher than 71.93%in the control group,the difference was statistically significant(P<0.05).The negative rate of HPV in the observation group after 3 and 6 months of treatment were higher than those of the control group after 3 and 6 months of treatment,the differences were statistically significant(P<0.05).After treatment,the pH of vaginal secretions in both groups were lower than those of before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 5.26%,lower than 14.04%of the control group,the difference was not statistically significant(P>0.05).Conclusion:Using lactobacilli to regulate the vaginal flora in the treatment of cervical HPV infection has a definite effect,which can significantly improve the negative rate of HPV,and is conducive to the recovery of vaginal microecology.