氟康唑与碳酸氢钠交替漱口预防鼻咽癌同步放化疗口腔真菌感染疗效观察

目的探讨氟康唑溶液与2.5%碳酸氢钠交替漱口预防鼻咽癌同步放化疗患者发生口腔真菌感染的临床疗效。方法将2016年1月至2017年6月收治的80例鼻咽癌同步放化疗患者随机分为两组,各40例。试验组患者采用氟康唑溶液与2.5%碳酸氢钠交替漱口,对照组患者采用生理盐水漱口。两组患者均首日放疗时及放疗后7,14,21 d给予给予咽部拭子培养进行真菌监测。结果试验组患者口腔的pH明显高于本组护理前(P<0.05),且明显高于对照组护理后(P<0.05)。试验组患者口腔真菌感染率明显低于对照组(P<0.05)。结论氟康唑溶液与2.5%碳酸氢钠交替漱口可明显提高患者口腔的pH,降低鼻咽癌放化疗患者的口腔真菌感染率。

Objective To investigate the clinical effect of fluconazole solution and 2.5%sodium bicarbonate alternative mouthwash in the prevention of oral fungal infection in patients with nasopharyngeal carcinoma(NPC)undergoing concurrent radiotherapy and chemotherapy.Methods From January 2016 to June 2017,80 patients with NPC were randomly divided into two groups,40 cases in each group.Fluconazole solution and 2.5%sodium bicarbonate were used alternately in the experimental group and normal saline was used in the control group.The patients in both groups were given throat swab culture for fungus monitoring during the first day of radiotherapy and 7,14 and 21 d after radiotherapy.Results The oral pH in the experimental group was significantly higher than that before nursing(P<0.05),and which was significantly higher than that in the control group after nursing(P<0.05).The infection rate of oral fungi in the experimental group was significantly lower than that in the control group(P<0.05).Conclusion Fluconazole solution and 2.5%sodium bicarbonate alternative mouthwash can significantly improve the oral pH and reduce the oral fungal infection rate of patients with NPC.