血清胃泌素17及胃蛋白酶原在健康体检人群胃癌筛查中的价值

目的探讨血清胃泌素17及胃蛋白酶原在健康体检人群胃癌筛查中的价值。方法选取医院2017年1月1日至12月1日收治并经胃镜检查及住院治疗的患者134例,按检查结果分为胃溃疡组(32例)、萎缩性胃炎组(23例)、非萎缩性胃炎组(50例)和胃癌组(29例),并根据肿瘤浸润胃壁的深度将胃癌组进一步分为早期胃癌组(9例)和进展期胃癌组(20例),检测血清胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ和胃泌素17水平。结果血清胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ和胃泌素17水平,胃癌组明显低于萎缩性胃炎组(P<0.05),早期胃癌组明显高于进展期胃癌组(P<0.05)。结论血清胃泌素17及胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ水平可提示胃癌和萎缩性胃炎,有助于提高胃癌诊断率。

Objective To investigate the value of serum gastrin 17 and pepsinogen in gastric cancer screening of healthy people.Methods Totally 134 patients with gastric ulcer(32 cases),atrophic gastritis(23 cases),non-atrophic gastritis(50 cases)and gastric cancer(29 cases)were divided into early gastric cancer group(9 cases)and advanced gastric cancer group(20 cases)according to the depth of tumor infiltration into the gastric wall.The serum pepsinogenⅠ,pepsinogenⅡand gastrin 17 were measured.Results The serum levels of pepsinogenⅠ,pepsinogenⅡand gastrin 17 in gastric cancer group were significantly lower than those in atrophic gastritis group(P<0.05),and those in early gastric cancer group significantly higher than those in advanced gastric cancer group(P<0.05).Conclusion The levels of serum gastrin 17,pepsinogenⅠand pepsinogenⅡcan indicate gastric cancer and atrophic gastritis,which is helpful to improve the diagnosis rate of gastric cancer.