2型糖尿病患者甲状腺功能与内脏脂肪面积的关系

Association of Thyroid Function with Visceral Fat Area in Type 2 Diabetic Patients

目的分析2型糖尿病患者甲状腺功能与内脏脂肪面积(VFA)的相关性。方法回顾性分析556例2型糖尿病患者的临床资料,依据内脏脂肪面积分为增多组和正常组,收集相关基本信息、血糖、血脂及甲状腺功能指标进行分析。结果相关分析显示,甘油三酯(TG)、游离三碘甲状腺原氨酸(fT 3)、ln促甲状腺激素(lnTSH)及年龄分别与VFA呈正相关,糖化血红蛋白(HbA1c)、高密度脂蛋白胆固醇(HDL-C)及游离甲状腺素(fT 4)分别与VFA呈负相关(P<0.05)。回归分析显示,fT 3,lnTSH,TG及年龄是内脏脂肪增多的危险因素(P<0.05)。结论在无显性甲状腺功能亢进或减退症及既往无其他甲状腺疾病史的2型糖尿病患者中,除了年龄及TG水平外,甲状腺功能中的fT 3及TSH水平升高是内脏脂肪增多的危险因素,提示甲状腺功能状态可能与内脏脂肪堆积密切相关。

Objective To analyze the correlation between thyroid function and visceral fat area(VFA)in type 2 diabetic patients.Methods A retrospective analysis of type 2 diabetic patients managed by the Metabolic Management Center of Fujian Medical University Union Hospital from February 2018 to May 2019 was divided into visceral adipose tissue(VAT)accumulation group and VAT normal group according to VFA.General information,blood glucose,serum lipids profile,and serum thyroid function indicators were collected and analyzed.Results Spearman correlation analysis showed that TG,fT 3,lnTSH,and age were positively correlated with VAT area,while HbA1c,HDL-C,and fT 4 were negatively correlated with VAT area(P<0.05).Regression analysis showed that fT 3,lnTSH,TG,and age were risk factors for VAT accumulation(P<0.05).Conclusion In patients with type 2 diabetes who have no overt hyperthyroidism/hypothyroidism and no previous history of other thyroid disease,elevated serum circulating fT 3 concentration and TSH level are risk factors for VAT accumulation in addition to age and serum triglyceride levels,suggesting that thyroid function status may be closely related to visceral fat accumulation.