超敏C-反应蛋白水平变化对血液肿瘤患者PICC导管相关性血栓判断价值的研究

The value of hypersensitive C-reactive protein level changes in the diagnosis of peripherally inserted central catheter related thrombosis in hematological malignancies

目的评估超敏C-反应蛋白(hs-CRP)水平变化与血液肿瘤患者PICC导管相关性血栓(PICC-CRT)的关系,指导临床及时采取必要措施。方法回顾性分析近8年内328例住院血液肿瘤患者血液hs-CRP水平变化与PICCCRT的相关性。根据多次检测的hs-CRP水平将患者分为3组:低hs-CRP组、高hs-CRP组及波动hs-CRP组,收集其hs-CRP等生化数据,对患者包括PICC导管相关性血栓进行审查。结果 3组患者之间的hs-CRP水平进行比较,差异均有统计学意义(P <0. 05);波动hs-CRP组PICC导管相关性血栓发病率显著高于高hs-CRP组、低hs-CRP组(P <0. 05);Cox回归分析结果显示hs-CRP分组是PICC-CRT的独立危险因素(P <0. 05)。结论 hs-CRP水平波动的血液肿瘤患者与PICC-CRT风险增加有关,指导临床重视并密切监测该类患者。

Objective To evaluate the relationship between the changes of high-sensitivity C-reactive protein(hs-CRP)level and peripherally inserted central catheter(PICC)catheter-related thrombosis(PICC-CRT)in hematological tumor patients,and to guide the clinical with timely measures.Methods The correlation between the changes of blood hs-CRP levels and PICC-CRT of 328 hospitalized hematologic tumor patients in the past 8 years was retrospectively analyzed.Patients were divided into three groups based on multiple hs-CRP levels:low hs-CRP group,high hs-CRP group,and fluctuated hs-CRP group,and biochemical data such as hs-CRP were collected for patients including PICC catheter correlation.The thrombus was reviewed.Results The hs-CRP levels were significantly different between the three groups,with the differences statistically significant(P<0.05).The incidence of PICC-CRT was significantly higher in the fluctuated hs-CRP group than in the high hs-CRP group and the low hs-CRP group(P<0.05);Cox regression analysis showed that the hs-CRP group was an independent risk factor for PICC-CRT(P<0.05).Conclusion Patients with hematologic malignancy with fluctuations in hs-CRP levels are associated with an increase risk in PICC-CRT,guiding clinical attention and closely monitoring such patients.