2型糖尿病患者血清补体C1q与颈动脉粥样硬化相关性的研究

Relationship between serum compliment protein C1q and carotid atherosclerosis in type 2 diabetes mellitus patients

目的探讨T2DM患者血清补体C1q与颈动脉粥样硬化(CAS)的关系。方法选取2017年6月至2018年6月于我院内分泌科住院的T2DM患者287例,根据补体C1q成人参考范围分为<159 mg/L、159~233 mg/L及>233 mg/L共3个组。检测各组临床生化指标。彩超测定颈动脉斑块及颈动脉内膜中层厚度(CIMT),分析血清补体C1q水平与上述指标的关系。结果补体C1q>233 mg/L组颈动脉斑块检出率高于<159 mg/L、159~233 mg/L组(P<0.05),补体C1q<159 mg/L、>233 mg/L组颈动脉斑块厚度高于159~233 mg/L组(P<0.05),补体C1q水平与颈动脉斑块厚度呈曲线相关(R^2=0.121,P<0.05),与CIMT无相关性(P>0.05)。结论血清补体C1q与CAS相关,可影响其发生发展。

Objective To explore the relationship between serum complement C1q and carotid atherosclerosis(CAS)in type 2 diabetes mellitus(T2DM)patients.Methods 287 T2DM patients hospitalized in the department of endocrinology of our hospital from June 2017 to June 2018 were selected.According to the complement C1q adult reference range 159~233 mg/L,they were divided into three groups of<159 mg/L,159~233 mg/L and >233 mg/L.The carotid plaque and carotid intima-media thickness(CIMT)were measured by color Doppler ultrasound.The relationship between serum complement C1q and the above indexes was analyzed.Results The detection rate of carotid plaque in the group of C1q >233 mg/L was higher than that in the group of <159 mg/L or 159~233 mg/L(P<0.05).The thickness of carotid plaque in the group of C1q <159 mg/L and > 233 mg/L was higher than that in the group of 159~233 mg/L(P<0.05).The level of C1q had a curve correlation with the thickness of carotid plaque(R^2=0.121,P<0.05),which had no correlation with CIMT(P>0.05).Conclusion Serum complement C1q is related to CAS,which may affect the development of CAS.