线粒体自噬与肺部疾病的研究进展

Progress in research on mitophagy and pulmonary diseases

线粒体自噬是选择性自噬的重要形式之一,可通过调控生物体内线粒体质量影响肺部疾病发生发展。线粒体自噬在不同的肺部疾病中发挥着不同的作用。如在特发性肺纤维化与急性肺损伤中,线粒体自噬水平过高或过低都可加重病情;而在肺动脉高压中,线粒体自噬水平过高时会产生损害效应。除此之外,在慢性阻塞性肺疾病中,线粒体自噬可调节细胞坏死以及控制细胞炎性反应。因此,深入了解线粒体自噬调控机制对肺部疾病的防治具有重要意义。

Mitophagy is one of the important forms of selective autophagy,which affects the occurrence and development of lung diseases by regulating the quality of mitochondria in vivo.Mitophagy has different functions in different lung diseases.In idiopathic pulmonary fibrosis and acute lung injury,excessive or low levels of mitophagy can aggravate the diseases;while in pulmonary hypertension,excessive mitophagy levels play the adverse effect in the progress of the disease.Additionally,in chronic obstructive pulmonary disease,mitophagy can regulate cell necrosis and control cellular inflammation.Therefore,it is important to understand the mechanism of mitophagy to prevent and treat lung diseases.