环境内分泌干扰物对早发性卵巢功能不全的作用机制研究进展

Environmental Endocrine Disruptors and Premature Ovarian Insufficiency

越来越多的证据表明,生命早期接触环境内分泌干扰物(EEDs)可引发卵巢结构和功能改变,表现为成年后生殖功能障碍。早发性卵巢功能不全(POI)是一种病因复杂的异质性疾病,75%~90%病因不明确为特发性POI。已明确表观遗传修饰和环境因素会导致生殖损害。EEDs从胚胎期便广泛暴露于人类生存环境中,可对女性生殖产生终生影响。以卵巢对EEDs尤其敏感的4个窗口(原始生殖细胞发育期、减数分裂期、原始卵泡形成期、卵泡的募集发育期)为切入点,综述EEDs对POI影响机制的最新研究进展。

More and more evidences suggest that early life exposure to environmental endocrine disruptors(EEDs)can cause the change of ovarian structure and function,following adult reproductive dysfunction.Premature ovarian insufficiency(POI)is a heterogeneous disease with complex and diverse etiologies,75%-90%of which are unknown idiopathic POI.The epigenetic modification and environmental factors have been identified to cause reproductive damage.Human even from embryo is widely exposed to environmental EEDs,and EEDs can have a lifelong impact on female reproduction.In this paper,the four windows of ovarian sensitivity to EEDs(included PGCs sdevelopment,Meiosis,PFs formation,follicles recruitment),and the mechanism of EEDs related to POI were reviewed.