摘要
越来越多的证据表明,生命早期接触环境内分泌干扰物(EEDs)可引发卵巢结构和功能改变,表现为成年后生殖功能障碍。早发性卵巢功能不全(POI)是一种病因复杂的异质性疾病,75%~90%病因不明确为特发性POI。已明确表观遗传修饰和环境因素会导致生殖损害。EEDs从胚胎期便广泛暴露于人类生存环境中,可对女性生殖产生终生影响。以卵巢对EEDs尤其敏感的4个窗口(原始生殖细胞发育期、减数分裂期、原始卵泡形成期、卵泡的募集发育期)为切入点,综述EEDs对POI影响机制的最新研究进展。
More and more evidences suggest that early life exposure to environmental endocrine disruptors(EEDs)can cause the change of ovarian structure and function,following adult reproductive dysfunction.Premature ovarian insufficiency(POI)is a heterogeneous disease with complex and diverse etiologies,75%-90%of which are unknown idiopathic POI.The epigenetic modification and environmental factors have been identified to cause reproductive damage.Human even from embryo is widely exposed to environmental EEDs,and EEDs can have a lifelong impact on female reproduction.In this paper,the four windows of ovarian sensitivity to EEDs(included PGCs sdevelopment,Meiosis,PFs formation,follicles recruitment),and the mechanism of EEDs related to POI were reviewed.
作者
闻鑫
张跃辉
姚美玉(审校)
WEN Xin;ZHANG Yue-hui;YAO Mei-yu(Graduate School,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Gynecology,The First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《国际生殖健康/计划生育杂志》
CAS
2020年第3期219-225,共7页
Journal of International Reproductive Health/Family Planning
基金
国家自然科学基金面上项目(81774136)
国家区域诊疗中心黑龙江省名中医传承工作室建设项目(黑中科教便函〔2019〕2号)
黑龙江中医药大学研究生创新科研项目(2019yjscx040)。