卵母细胞滑面内质网聚集体的研究进展

The Research Progress of Smooth Endoplasmic Reticulum Aggregates in Oocytes

滑面内质网聚集体(smooth endoplasmic reticulum aggregates,SERA)指卵母细胞滑面内质网异常聚集成簇。在辅助生殖过程中,SERA可能出现在任何类型的促排卵周期。有研究表明,SERA对卵母细胞的受精率、胚胎的囊胚形成率和妊娠结局均有一定的负面影响。但是关于这种影响存在与否,程度如何,目前存在争议。本文对卵母细胞SERA的研究进展进行综述。对于SERA的产生原因、造成结果及补救方法的系统研究,可以帮助生殖医生在临床工作中更好地应对SERA的发生。

Smooth endoplasmic reticulum aggregates(SERA)refers to the abnormal oocytes smooth endoplasmic reticulum gather into a cluster.During assisted reproduction,it can occur in any type of ovulatory cycle.Studies have shown that SERA has certain negative effects on the fertilization rate of oocytes,blastocyst formation rate of embryos and pregnancy outcome.But there is debate about whether and to what extent this effect exists.Therefore,this paper reviews the research progress of oocyte smooth endoplasmic reticulum aggregation.Systematic research on the causes,results and remedies of SERA can help fertility doctors better deal with the occurrence of SERA in clinical work.