人绒毛膜促性腺激素在胚胎移植中的研究进展

Research Progress of Human Chorionic Gonadotropin Adminstration in Embryo Transfer

自20世纪90年代中期以来,辅助生殖技术(ART)取得了很大进展,但移植后的胚胎种植率却相对较低。胚胎植入是一个复杂的过程,涉及到胚胎与子宫内膜之间的相互作用。在参与作用的众多因素中,人绒毛膜促性腺激素(hCG)起着关键作用。hCG作为胚胎在着床前分泌的早期胚胎信号之一,其mRNA早在胚胎8-细胞阶段就已开始转录,而囊胚在种植前就已开始表达hCG。已有研究表明,hCG作为胚胎植入的早期重要介质,可通过改善子宫内膜容受性,促进子宫内膜蜕膜化、血管生成、滋养细胞侵袭和调节母体免疫耐受,从而有利于胚胎成功着床。综述hCG在胚胎移植中的最新应用与研究进展。

Although great progress has been made in assisted reproductive technology(ART)since the mid-1990 s,the embryo implantation rate after transfer is relatively low.Embryo implantation is a complex process involving the interaction between the embryo and the endometrium.Among the many factors involved in implantation,human chorionic gonadotropin(hCG)plays a key role.As one of the early embryonic signals secreted by embryos before implantation,h CG mRNA began to transcribe as early as the embryonic 8-cell stage,while blastocysts began to express hCG before implantation.Studies have shown that hCG,as an important medium in the early stage of embryo implantation,promotes the endometrial decidualization,angiogenesis,trophoblast invasion and maternal immune tolerance by improving endometrial receptivity,which is beneficial to successful embryo implantation.In this paper,we summarize the application of human chorionic gonadotropin in embryo transfer and its research progress.