PHC联合HP在急性重度有机磷农药中毒治疗中的作用

The Effect of PHC Combined with HP in the Treatment of Acute Severe Organophosphorus Pesticide Poisoning

为观察盐酸戊乙奎醚(PHC)联合血液灌流(HP)治疗急性重度有机磷农药中毒的临床疗效,将81例急性重度有机磷农药中毒患者随机分为治疗组(N=42)和对照组(N=39),治疗组行PHC联合HP治疗,对照组单用PHC,比较两组之间APACHE-Ⅱ评分、昏迷恢复时间、机械通气时间、治愈时间、入住ICU时间、住院时间、MODS发生率和28 d病死率。结果显示:治疗组的APACHE-Ⅱ评分、昏迷恢复时间、机械通气时间、治愈时间、入住ICU时间、住院时间均低于对照组(P<0.05),治疗组的MODS发生率和28 d病死率显著低于对照组(P<0.01)。结果表明:PHC联合HP治疗急性重度有机磷农药中毒疗效优于单用PHC。

The purpose of this study was to observe the clinical efficacy of PHC combined with HP in the treatment of acute severe organophosphorus pesticide poisoning.81 patients with severe organophosphorus pesticide poisoning were randomly divided into therapeutic group(N=42)and control group(N=39).The therapeutic group received PHC combined with HP,and the control group received PHC alone.APACHE II score,coma-recovery time,mechanical ventilation time,healing time,in-ICU time,in-patient time,the incidence of MODS and 28-day mortality were compared between the two groups.The coma-recovery time,mechanical ventilation time,and healing time,in-ICU time,in-patient time were lower in the therapeutic group than in the control group(P<0.05),the incidence of MODS and 28-day mortality were significantly lower than in the control group(P<0.01).Thus,PHC combined with hemoperfusion exerts a better therapeutic effect in acute severe organophosphorus pesticide poisoning than PHC alone.