p62/SQSTM1与自噬在胃癌组织中表达及临床意义

Expression and Clinical Significance of p62/SQSTM1 and Autophagyin Gastric Cancer

观察p62/SQSTM1(简称p62)在胃癌组织中的表达水平,探讨p62与自噬的关系及临床意义。采用免疫组织化学检测胃癌石蜡标本中p62的表达情况,并分析p62与临床病理资料及预后的关系,同时检测胃癌和癌旁新鲜组织中p62 mRNA及蛋白的表达水平。结果,190例胃癌石蜡标本中p62阳性率高于癌旁正常组织(P<0.05);p62的表达与浸润深度、淋巴结转移、临床分期有关(P<0.05);p62阳性患者5年生存率为33.2%,低于p62阴性患者的55.3%(P<0.05);在新鲜胃癌组织中,p62 mRNA和蛋白的表达水平显著高于相应癌旁正常组织。结果表明:p62促进胃癌的发生发展及转移,是评估胃癌术后患者预后的一个重要标志。

This paper examined the expressions and clinical significance of p62/SQSTM1 in gastric cancer,and the relationship between p62 and autophagy.The expression of p62 protein was detected in paraffin specimens of by the immunohistochemical staining.The relationship between the expression of p62 and clinicopathologic data and prognosis was analyzed.The expression level of p62 mRNA and protein in fresh gastric carcinoma samples were examined.The positive percentage of p62 proteins in 190 paraffin blocks of the gastric cancer was significantly higher than that of matched paracarcinoma tissues(P<0.05).The expression of p62 was significantly correlated with depth of invasion,lymphatic metastasis,pathological stage(P<0.05).The 5-year survival rate of patients with p62 positive was 43.2%,significantly lower than those of 51.3%with p62 negative(P<0.05).The expression level of p62 mRNA and proteins in flesh gastric cancer samples were significantly higher than corresponding beside tissue.p62 promotes the generation and evolution of gastric cancer,and is an important symbol of prognosisafter surgery.